I get so frustrated I have been on Effexor for a few years now. I had to have it increased from 75 by adding a 37.5. Perhaps someone who struggles with depression would understand how frustrating it is to know that without this medication whether I want to or not, I am not ok. I ran out of the half doses the other day and because I had just started back on that dose I thought I would be okay until I got paid. Well all day yesterday I was weepy, couldn't sleep all night. I had to take 3 mg of lorazapam to get my body to fall asleep and that was after being up all night. My husband is better at understanding....I sometimes wish I could just stop the whole thing. Inside I feel less because I must live on these pills. God I wish I knew someone who really got how I feel. When not on my meds, I have terrible thoughts, cry all the time, loose my mind over stupid things, like get rantin and raving over things that are very little. I would love to hear from someone on here to knows or can related I need help understanding if I am normal to anyone else in this freakin world.