I found this interesting and thought others might whether they were dealing with thrush, chronic sinutitus, overgrowth of candida in gut or systemic candida. I was unable to take either, due to sensitivity, and used Berberine Complex (Barberry "berberine vulgaris", Oregon Grape, "Berberine Aquifolium", and Goldenseal), for systemic candiasis. Best wishes, LL Difference Between Diflucan and Nystatin: Diflucan and Nystatin are very different in their action. Diflucan is a systemic anti-fungal that reaches the yeast mainly by way of the blood stream. Although swallowed, most Diflucan is absorbed into the blood stream through the intestine wall and works systemically. Unfortunately, very little remains in the intestine, so intestinal Candida may be supressed but will not be eradicated by Diflucan. Nystatin is actually extracted from bacteria and does not pass through the intestinal walls. It therefore remains in the intestines at full concentration. If used simultaneously in both mouthwash and tablets form, Nystatin will kill off GI candida from the mouth to the anus, but will not affect any Candida outside the GI tract.