never, i cant think or remember any time at all that i havent had some pain with this stuff. it has now been like-atleast i suppose the late 80's ive had this and couldnt find a dr back then... and with the poly migratory arthrits to- i know that also is a factor. i forget what it feels like to have no pain! right now as i sit here and even with a pain patch on... i m hurting so bad - esp. in my neck that i wish i could cut it off. ok i know that sounds sick.. . but man!!! what does it take to not have pain??