I am just curious what your experience has been. I have been taking lexapro and nortryptyline (very low dose) and I did slowly recover from malaise. I never got rid of pain though although it was not as bad as before. I had more energy, my thoughts were more clear. However I have gained 35 to 40 lbs and the pain was bad so I decided to see what would happen if I stopped. the dr did not think it was a good idea to take both and wanted to try cymbolta. This happened in June. For a while I did not notice any major difference. But by November I started to regress. I even have malaise that I did not experience for the last three years. So of course I am second guessing my decision. I just do not know if this would happen anyway or if it is because I stopped. By the way, I have not lost weight either. So now I am curious if anyone's experience was similar. Any opinions? I have just posted in another thread. The malaise is the worst symptom for me. I can tolerate just about anything but because I have to work this one frightens me because I cannot function with that at all.