I think methylation is just another ripoff. If you are not overstimulated you might perceive stimulation as improvement tough. It is so funy to see how overstimulation, anxiety and other nice side effects are interpreted as "detox syptoms". I know many CFS patients and all of them are overstimulated to some degree. I do not think that stimulating medications or dietary supplement could do anything good. The worst thing is that people experiment on us but no one has a clue what to do when side effects come up. My heavy metal provocation test for instance considerably improved but I have never been so anxious. It was not worth. I do not see any symptomatic imrovement. Heavy metals did not bother me at all.