Does anyone know what this test means Growth Factor I

Discussion in 'Fibromyalgia Main Forum' started by Rosetta, Aug 25, 2005.

  1. Rosetta

    Rosetta New Member

    I had some blood work done and the Insulin-Like Growth Factor I came back low 81 and normal is 97-238. Also, my Immunoglobulin A (559 and normal was 70-400) and Immunoglobulin M (242 and normal is 40-230) both came back high. I took these results to my doctor and she did not know what they were. She is suppose to find out but if anyone knows I would really appreciate any information. I got these results as part of a study because our drinking water is contanimated with C8.

    I have FM and thyroid.

  2. Shirl

    Shirl New Member

    Shalom, Shirl
  3. tilla

    tilla New Member

    I have the IGF test for Growth Hormone done a lot. Mine started out at 80 and I have gotten my up to 223 with HGH shots. I don't know if I reccommend it though.

    My brother-in-law is head of Blood Work area at Stanford and he did not know that an IGF blood count was.

    I also have FM and throid problems. I have just started an oxygen machine at night as I may have sleep apnea. Sleep apnea will also cause your IGF to be low.

    Tilla
  4. Rosetta

    Rosetta New Member

    I also have sleep apena. Thanks for the information.
  5. fibromaster

    fibromaster New Member

    How is it used?
    IGF-1 is measured to help diagnose the cause of growth abnormalities and to evaluate pituitary function. IGF-1 levels reflect integrated GH status and, along with GH provocation tests, are used to help diagnose GH deficiency. These tests, while generally ordered in children suspected of GH abnormalities, may also be used in adults with GH deficiency. IGF-1 levels and the measurement of GH also provide information related to GH Insensitivity (GHI).
    IGF-1 also may be ordered with other pituitary hormone tests, such as ACTH (Adrenocorticotropic hormone), to help diagnose hypopituitarism. It also may be used to monitor the effectiveness of treatment for growth hormone deficiencies and GHI.

    IGF-1 testing and a GH suppression test can be used to detect a GH-producing pituitary tumor. Its presence is then confirmed with imaging scans that help identify and locate the tumor. If surgery is necessary, GH and IGF-1 levels are measured after the tumor’s removal to determine whether or not all of it was successfully removed. Drug and/or radiation therapy may be used in addition to (or sometimes instead of) surgery to try to decrease GH production and return IGF-1 to normal or near normal concentrations. IGF-1 may be used to monitor the effectiveness of this therapy at regular intervals for years afterward to monitor GH production and to detect tumor recurrence.

    When is it ordered?
    IGF-1 testing may be ordered, along with a GH stimulation test, when a child has symptoms of GH deficiency, such as a slowed growth rate and short stature. They also may be ordered in adults with suspected GH deficiency. An IGF-1 also may be ordered when a doctor suspects that a person has an underactive pituitary gland. In addition, IGF-1 levels are ordered to monitor patients on GH therapy.
    IGF-1 testing may be ordered, along with a GH suppression test, when a child has symptoms of gigantism, an adult shows signs of acromegaly, and/or when a doctor suspects that a patient has hyperpituitarism.

    When a GH-producing pituitary tumor is found, GH and IGF-1 are ordered after the tumor is surgically removed to determine whether all of the tumor has been extracted. IGF-1 also is ordered at regular intervals when a patient is undergoing the drug and/or radiation therapy that frequently follow tumor surgery.

    IGF-1 levels may be ordered at regular intervals for many years to monitor a patient’s GH production and to watch for pituitary tumor recurrence.


    What does the test result mean?
    NOTE: A standard reference range is not available for this test. Because reference values are dependent on many factors, including patient age, gender, sample population, and test method, numeric test results have different meanings in different labs. Your lab report should include the specific reference range for your test. Lab Tests Online strongly recommends that you discuss your test results with your doctor. For more information on reference ranges, please read Reference Ranges and What They Mean.


    If IGF-1 concentrations are decreased, then it is likely that there is a deficiency of GH (GH Deficiency; GHD) or an insensitivity to GH (GH Insensitivity; GHI). If this is in a child, the GH deficiency may have already caused short stature and delayed development and may be treated with GH supplementation. While it is normal for adult levels to be lower than those in children because of an age-related decrease in production, adults also may have low IGF-1 due to GHD or GHI and will need to be treated.
    If a decrease in IGF-1 is due to a more general decrease in pituitary function (hypopituitarism), then several of the patient’s pituitary hormones will need to be evaluated and may be supplemented to bring them up to normal levels. Reduced pituitary function may be due to inherited defects or can rise as a result of pituitary damage following conditions such as trauma, infections, and inflammation.

    Decreased levels of IGF-1 also may be seen with nutritional deficiencies (including anorexia nervosa), chronic kidney or liver disease, inactive/ineffective forms of GH, and with high doses of estrogen.

    Elevated levels of IGF-1 usually indicate an increased production of GH. Since GH levels vary throughout the day, IGF-1 concentrations are a reflection of average GH production, not of the actual amount of GH in the blood. This is accurate up to the point at which the liver’s capacity to create IGF-1 is reached. With severely increased GH production, IGF-1 levels will stabilize at an elevated maximum concentration.

    Increased concentrations of GH and IGF-1 are normal during puberty and pregnancy but otherwise are most frequently due to pituitary tumors (usually benign). If other pituitary hormones are also abnormal, then the patient may have a condition causing general hyperpituitarism.

    If IGF-1 is still elevated after the surgical removal of a pituitary tumor, then the surgery may not have been fully effective. Decreasing IGF-1 concentrations during subsequent drug and/or radiation therapies indicate that the treatment is lowering GH production. If levels of IGF-1 become “normalized,” then the patient is no longer producing excess amounts of GH. When a patient is undergoing long term monitoring, an increase in IGF-1 levels may indicate a recurrence of the pituitary tumor.

    ------------------------------------------------------------

    Biologic properties of antibodies: The amino acid structure of the C region of the heavy chain determines the isotype of that Ig class. Each class serves different functions.

    IgM, the first Ab formed after primary immunization (exposure to new Ag), protects the intravascular space from disease. Pentameric IgM molecules readily activate complement and serve as opsonizers and agglutinators to assist the phagocytic system to eliminate many kinds of microorganisms. Isohemagglutinins and many Abs to gram-negative organisms are IgM. Monomeric IgM serves as an Ag receptor on the B-cell membrane.

    IgG, the most prevalent type of serum Ab, is also found in extravascular spaces; it is produced when IgM titers begin to decrease after primary immunization. IgG is the major Ig produced after re-immunization (the memory immune response or secondary immune response). IgG protects the tissues from bacteria, viruses, and toxins. IgG is the only Ig that crosses the placenta. Different subclasses of IgG neutralize bacterial toxins, activate complement, and enhance phagocytosis by opsonization. Commercial -globulin is almost entirely IgG, with small amounts of other Igs.

    IgA is found in mucous secretions (saliva, tears, respiratory, GU and GI tract, and colostrum), where it provides an early antibacterial and antiviral defense. Secretory IgA is synthesized in the subepithelial regions of the GI and respiratory tracts and is present in combination with locally produced secretory component (SC). Few cells that produce IgA are found in the lymph nodes and spleen. Serum IgA does not contain SC. Serum IgA provides protection against Brucella, diphtheria, and poliomyelitis.

    IgD is present in serum in extremely low concentrations but also appears on the surface of developing B cells and may be important in their growth and development.

    IgE (reaginic, skin-sensitizing, or anaphylactic Ab), like IgA, is found primarily in respiratory and GI mucous secretions. In serum, IgE is present in very low concentrations. IgE interacts with mast cells; bridging of two IgE molecules by allergen may cause degranulation of the cells, with the release of chemical mediators that cause an allergic response. IgE levels are elevated in atopic diseases (eg, allergic or extrinsic asthma, hay fever, and atopic dermatitis), parasitic diseases, far-advanced Hodgkin's disease, and IgE-monoclonal myeloma. IgE may have a beneficial role in the defense against parasites.

  6. Defibro

    Defibro New Member

    This is very informative.

    My IGF-I is 139 ng/mL, it looked good to me according to the lab reference range (71-290).

    But the Dr. at the FFC said; that is low , it should be around 200, or better, so he gave me a prescription for GH.

    My daughter, who is a clinical Pharmacist, told me not to take yet, until I build up my thyroid, that the GH will not work efficiently, until my thyroid are balanced.

    The Dr. also put me on T3, although my level of T3 was OK, but the ratio of T3 to reverse T3 was only 1.7, it needs to be around 3 (you divide rev.T3 by T3).

    It remains to be seen, if this will help my fatigue, pain, almost constant hot flashes, and insomnia. I just hope to get some relief, 40% will do.