I started taking Lyrica, 50 mg. 3 x daily. I can't tell that it is helping but I have only been taking it 5 days. My pain level is up. But I recently stopped both cymbalta and my anti-inflammatory. My arthrits is really kicked up a notch as a result. The weather here in Tennessee has been rainy and cooler which hasn't helped. Do any of you take other pain meds while on the Lyrica? The doctor said to take it instead of the ultram. I have some lortab and lorcet that I was prescribed for days when the pain is worse, but am not taking presently. I'm thinking I may have to stop the lyrica and take lorcet. I want my cymbalta and celebrex back! But I did have good reasons to stop them, I admit. But they really helped my pain level. So...I am wondering if it took awhile for the lyrica to kick in and if I just need to hang in there longer. If this is good as it's going to get on the lyrica, I'm ready to toss them!