Last time I had a flare I didn't know I had FM. I was taking 3 ibuprofen every 4 hours around the clock. This flare is worse, but now that I have acid reflux I'm not supposed to take ibuprofen anymore. I have been taking ultram, but my doctor told me to take just one pill every six hours. When he gave it to me a month ago, I was doing fine with one per day. Now I'm taking them around the clock, and sometimes I give in and add 2 ibuprofen to it because otherwise I can't keep working. I keep thinking this flare is the worst ever and it can't get any worse, but every day it's worse. I see some of you on things like oxycontin and even morphine and it scares me to death. Does using pain relievers like this make the brain even less able to deal with pain, so that the pain continues to increase as time goes by? Should I grit my teeth, so to speak, and avoid using my ultram unless I have a migraine? Help!