I have had CFS/EB/Fibro for 3.5 years. My worst, worst symptom is my sore throat. I can't take the pain. Many doctors have suggested anti-depressants, which I have refused to take because for many, they cause significant weight gain (a few friends have done gastric bypass after being on them, coming off, and never ever being able to lose weight again) I am overweight to begin with, I don't want my system to go more out of whack than it has. For those taking Savella, have you gained weight? Thank you.