I get up in the morning and take my first round of medications go back to sleep for awhile until the medicine starts working then about four hours later i take my next round of medicine and i feel a little better. four hours later i take the next round and then by dinner time, i feel good. it seems like it takes a long time for the meds to really kick in. of course i am never pain free. well living with FM is so much fun lol! God Bless all of you!