I noticed a difference two weeks after starting Cholestyramine (Questran, plain not diet or flavored). Now after a month, I could do cartwheels. It is like night and day. Friends and their husbands are also commenting on how big a change I have made. Some of these people do not know I am taking this medicine. I still do not understand exactly how to schedule this medicine with my meals. (I have some memory problems not related to FM.) Even without taking this "correctly" I have had excellent results. My schedule of taking it is as follows; I take it when I remember, sometimes once, twice or three time a day. I do not get hung up on the schedule. I recommend trying Cholestyramine. I still have FM problems, it has not cured me. But the fog has lifted and I feel that I can live a life.