I have been on 60 mg a day since Jan 05, can tell some difference, I went off it about two months ago because I didnt have the $95 to pick it up, after about a week my depression grew enormously (suicide thoughts) went to family dr. she said you can't do that,uped my depression pill and I went and bought my cymbalta, started doing better, well about a week ago I didnt have the money to get it again, the last 3 days have been hell. Today, I have been a total wreck,I hate my own self, I've hollered at my 4 yr. old that I never holler at. Just want to pull my hair out, It's like leave me ALONE to everyone. I totally feel like I am losing my mind.Know matter what, I will be at the pharmacy TOMORROW. If I ever go off again I WOULD TRY TO WEENE MY SELF OFF NEXT TIME. It has to be that, I havent done nothing else different.Please take my advice,you don't wanta feel the way I am right now.