Doxy info and experience?

Discussion in 'Lyme Disease Archives' started by foggyfroggy, Mar 12, 2008.

  1. foggyfroggy

    foggyfroggy Guest

    Hello y'all,

    I'm wondering about peoples experiences with Doxy as I like to go into taking new meds with as much knowledge as possible.

    Anyone had a negative experience with it?

    What are or have been your dosages?

    My bottle says take with food but my info sheet says take on empty stomach. Any ideas?

    I know not to take it with minerals or dairy, but anyone noticed anything else?

    Thanks!

    Gretchen
  2. mrdad

    mrdad New Member

    Boy! Seems like ya just can't go anywhere without seeing me
    just "show up"! Ya know what I'm sayin?

    OK, just for a short moment, I'm gonna be serious. I'm just
    finishing (4 days left) a 28 day protocol of Doxy 100mg 2x
    a day. If you read the attached paper work with the Doxy,
    mine indicates to take 1hr before meals or 2 hrs. afterward.
    You can take with some food if nausea occurs, even maybe a
    piece of toast, I'm thinking?

    I haven't had any negative "herxing" etc. but not sure if that
    is good or a bad thing? Possibly Victoria would know.
    Just gonna play it by ear for now. I tend to think, Froggy,
    that every person reacts differently.

    After almost four weeks, I see NO change at present.(??)

    Huggles,
    MRDAD





  3. victoria

    victoria New Member

    NO herxing? That's not a good sign.

    My son's LLMD and most research would say that the doxy didn't work then... ie, the only way one knows the critters are getting killed is because you herx to the toxins. So his LLMD wouldn't be surprised to hear you feel no difference.

    There are over 300 varieties of Bb worldwide, and quite a few within the US... then there's the other tick-born infections to also consider. Anyway, different varieties of Bb respond to different abx, altho often doxy is the first tried and most talked about from the beginning.

    IF I remember right, my son for an example actually started with septra and 1 other abx which I can't remember right now, plus flagyl (for the cyst form). After a 3 week pulse during which he continually herxed, he definitely felt better the 4th week. Then of course he kept repeating the pulses.

    Septra and flagyl are still his mainstays for lyme, altho other abx have been used as indicated for apparent bartonella and babesia.

    all the best,
    Victoria

  4. foggyfroggy

    foggyfroggy Guest

    Thanks Mrdad,

    Your dose does seem lower than a couple of other people have said - a lot say 400 mg and one paper even said 600!
    I will go with what your paperwork said since mine is conflicting. Yours at least agrees with half of mine ;-)

    Victoria, I don't remember seeing Septra on the list I recently read. What class is it in, do you know?

    Mrdad and I probably (maybe) would have the same 'strain' since we're both West Coasters.

    Thanks guys,
    Gretchen
  5. mrdad

    mrdad New Member

    Thanks Victoria. I was pretty sure that would be your respon-
    se to the "non-herxing". Could be that my mg's weren't enough
    and/or it didn't go long enoungh. I'll bet this is most oft
    a process of elimination until the proper protocol and A B is
    arrived at? Could take lots of time and effort I would think.

    Oh, Froggy, somethin' tells me that O.J with anti-biotics is
    a No-No also. (But don't quote me on that!) But Froggy, I'm
    impressed with your personal research and the your ability to
    process the info thoughtfully and constructively! Good Girl!!
    I learn as you learn! We're all in this together.

    Huggles,
    MRDAD

    P.S. Pharmacist says to avoid calcium and (Rolaids etc).[This Message was Edited on 03/12/2008]
  6. victoria

    victoria New Member

    "SEPTRA (trimethoprim and sulfamethoxazole) is a synthetic antibacterial combination product. Each SEPTRA Tablet contains 80 mg trimethoprim and 400 mg sulfamethoxazole."

    He's also taking Azithromax with the septra, at this point I don't remember for what exactly - but most- if not all- of these abx treat more than one type of bacteria that could be or are likely to be present... flagyl is always pulsed and is EXTREMELY necessary to take btw... only thing that gets the cysts...

    There's an interesting thread over at Lymenet about which abx have been found useful on a 1st hand basis, rather interesting to read, answers are about as varied as you could imagine:
    http://flash.lymenet.org/ubb/ultimatebb.php?ubb=get_topic;f=1;t=000465

    It certainly shows that many try a variety of abx at the very least!

    Here's also some interesting info about varieties, altho i've read since 2006 (when this was written) that they have isolated a few other distinct 'types', one notably only in a Wisconsin valley.

    "LD is caused by many borrelia species. Another major oversight by the medical community regarding Lyme disease is that Borrelia burgdorferi is not the only bacterium that causes Lyme disease; there are many pathogenic borrelia strains; many of which cause borreliosis (Lyme-like disease).

    "The causative agent, Borrelia burgdorferi, is a type of spirochete. When Bb was first discovered in 1982 it was thought that there was just one strain. Since then, about 100 U.S. and 300 worldwide strains of the bacterium have been discovered.

    "In the mid-1990's genospecies were formed to group the many variations into subcategories.

    "Borrelia burgdorferi sensu lato is name given to the overall category. In North America there is just one genospecies variant - Bb sensu stricto. In Europe there are 3 categories Bb sensu stricto, B. garinii, and B. afzelii. Asia has B. garinii and B. afzelii. Japan has B. japonica and B. miyamoto. These groups are evolving as new research discoveries occur.

    "A new pathogen causing Lyme or "Lyme-like" disease has been reported. While not culturable, it has been named B. lonestari sp.

    "B. andersonii, B. lonestari and B. miyamotoi have been identified by PCR and DNA sequence analysis as likely human pathogens in the U.S. Unfortunately, the criteria for clinical Lyme are set for only Borrelia burgdorferi; they were not designed for any other borrelia species.

    "The reason that Borrelia burgdorferi is tracked by health officials but not other species is because it’s the primary borrelia species that laboratories are able to identify and study. I admit that Borrelia species are very difficult to grow (fastidious) and work with in the laboratory. In most cases, laboratories are not even able to isolate and identify Borrelia species.

    "Some other known strains of borrelia include: B. valaisiana, B. lusitaniae and B. bissettii."
    -- Scott Taylor DVM who has had lyme himself.




    [This Message was Edited on 03/12/2008]
  7. victoria

    victoria New Member

    I don't think the lack of herxing is due to not taking the doxy long enough - herxing occurs quite quickly normallly.

    I HAVE heard that some do not ever herx... but I don't know how factual that is with long-term/late-stage Lyme. I've talked to my son's LLMD about it, he doesn't believe that's true in his experience, and it's hard for me to believe from talking to others & reading other's posts.

    Not sure if there's ever been a really good (very large number of pts) study of this to know if it's true or not?

    But - bottom line if you don't feel any different in any way, good or bad, your doctor should be trying something else... and adding in the flagyl in any case. LOL, don't mean to harp on the flagyl, but it is so important...

    best,
    Victoria



  8. Daisys

    Daisys Member

    That was the first abx I was put on. My LLMD told me to eat plenty with it, and I definitely herxed taking it with food.

    I read somewhere that taking it with food slowed down it's peak strength in the system, but it still got out there to do it's thing eventually.

    I guess it can be really hard on the stomach.

    The one thing I know that you didn't list is not to lie down for an hour after taking it. If it backs up your esophagus, it can be just as hard on that as your stomach.

    It was effective for me at 200mg x 2 daily, with ceftin.
  9. mrdad

    mrdad New Member

    I just read your Bio and do hope that you in deed will be
    be feeling better soon. Your Doctors instructions are opposite
    to the ones on the Med Instructions from Walgreen's Pharmacy?
    I would think that the reason for an empty or near empty stomach would be to facilitate quicker and concentrated absortion into the system.(?)(?) I'll have to do what my
    Dear 'old Mom did years ago and write Dr Marcus Welby on T.V. to
    get the real deal! I'm sure he knows.

    Victoria, you are most likely correct in that I don't think
    the 200mg's a day of Doxy was enough to create a "Herx"!
    As I mentioned, I am going to "push" for a Specialist maybe
    at UCSF teaching hospital. Lots of med research is done ther
    likewise. Don't believe that my N.P., as knowledgable as
    she is in the Med field, hasn't the experience deal with
    Lyme. I'll take it from there and see where it goes.(?)

    Good night Ladies!
    MRDAD

  10. foggyfroggy

    foggyfroggy Guest

    Mrdad, if you think I am 'thoughtful and constructive' you are one sadly deluded guy (grin). And O.J. belongs behind bars.
    Seriously, thanks for the support and the info. I know you are gathering info just as I am, and I hope we both benefit soon!

    Victoria, you are a true mine of information and I know you have helped many on the board. Thanks for the links, I will do a bunch more reading tomorrow.

    Daisys, it sounds like you are being helped and that is great! I am glad to hear you could eat and it still worked; I've been afraid I wasn't getting anything out of it because I had it with meals. I will watch the esophagus thing as I have trouble with that anyway since I lay here so much. Thanks.

    Well, off to bed for me. I am having some weird and scary stuff going on tonight. Hope it's herx and not some new thing to panic over.

    Love to all,
    Gretchen
  11. wld285

    wld285 New Member

    I started on 200 mg 2x a day for a week, then 100 mg 2x a day. The first time I had severe fatigue and this time only one day of herxing. I don't think I am a herxer. Hopefully that doesn't mean it's not helping me.

    Also no dairy or calcium within 2hrs. each way. You need to eat something, I usually have a piece of toast in am and something small in the eve.

    Linda
  12. mrdad

    mrdad New Member

    Funny, did you have prior knowledge that O.J and I both at-

    tended CCSF and shared a class together? And it was a "GOLF"

    class! As they say on that T.V. program, "Believe it or don't"


    Huggles,
    MRDADS

    P.S. And went to H.S. with Dan White! My claim to fame has
    been that I have "low friends in high places".
  13. foggyfroggy

    foggyfroggy Guest

    Well I may have known that but with my colander brain things tend to just run on through unless extra chunky!
    Pretty amazing, now I can say I know someone who knows someone . . . . . .

    I am embarrassed to say I had to Google Dan White, but then I did sorta remember. What a sad sad thing. It said he was a paratrooper in Nam. I don't know if it has anything to do with it or not but I knew someone who was a paratrooper in Nam and he was mentally way way damaged. He had fits of violent depression. So perhaps it wasn't just the Twinkies.

    Over and Out!

    Gretchen
  14. mrdad

    mrdad New Member

    Extremely sad especially for his parents, wife and children!

    They are filming presently in SF about the tragedy in the

    film called "MILK". My older brother (now deceased) worked

    across the Hall from where it occurred, as it happened!

    Dan was in my Homeroom for there years and hardly remember

    having had more than a few words with him!(?)

    Anyway, have a dry weekend and keep up "the good fight".

    Huggles,
    MRDAD