Dear All, I went to Barnes and Noble last to look at FM books. I looked at probably 10 books. The one that stood out to me the most was a book by Dr. Pellegrino. He claims to suffer from FM and to have to have treated thousands of diagnosed FM sufferers. He claims that AntiBiotics does work for some with FM. I'm thinking that FM (as I have read in other places) is a waste basket diagnoses. IOW other diseases including mycoplasma blood infection are lumped into the FM diagnoses. So not one treatment going to work for everyone. Maybe this is why we see mixed responses on long term uses of AnitBiotics. Excerpt from Dr. Pellegrino book below: "Antibiotics can have a role in treating fibromyalgia. Dr. Garth Nicolson has isolated a microorganism, Mycoplasma fermentens, as a possible infectious cause of Gulf War Syndrome (remember, this may be a type of fibromyalgia). Some patients had less pain and fatigue after taking antibiotics (for example, doxycycline, Zithromax), presumably due to the eradication of the Mycoplasma. Antibiotics may also inhibit certain enzymes that cause inflammation (anti-inflammatory mechanisms) rather than by acting as an anti-infection mechanism. I have had some patients who improved after a course of antibiotics and many who did not, so I’m not convinced that these drugs are helpful for the long term. Antibiotic use increases one’s chance of getting a Candida yeast infection, which can increase fibromyalgia symptoms. Over time, we may identify a specific subgroup of fibromyalgia patients who have antibiotic-responsive symptoms."