Drug relieves FM pain: Study

Discussion in 'Fibromyalgia Main Forum' started by CelticLadee, Mar 22, 2003.

  1. CelticLadee

    CelticLadee New Member

    I just read this article and thought I would paste it here for all of you to read.

    Drug Relieves Fibromyalgia Pain: Study
    Fri Mar 21, 2:32 PM ET

    NEW YORK (Reuters Health) - An antidepressant medication helps reduce pain in people with fibromyalgia, a chronic pain condition for which there is currently no approved treatment, according to the results of a study reported Friday.

    The lead investigator told Reuters Health that he hopes to begin the last phase of studies required before a company can apply for U.S. Food and Drug Administration (news - web sites) approval later this year.

    Fibromyalgia is a chronic condition marked by widespread muscular and joint pain, as well as specific "tender" points that typically occur in the neck, spine, hips and shoulders. Other symptoms include sleep disturbances and fatigue, depression and irritable bowel syndrome. The condition affects an estimated 2% to 4% of the population, but is seen most often in women of reproductive age.

    The pain associated with the syndrome does not originate from trauma, inflammation, or nerve damage, but seems to be due to a disturbance in pain processing that originates in the brain.

    There are no approved drug therapies for fibromyalgia, but it is usually treated with tricyclic antidepressants. Those drugs cause dry mouth, weight gain and other side effects.

    Milnacipran, the drug being studied to treat fibromyalgia, is approved to treat depression in 22 countries, including France and Japan. Milnacipran belongs to a class of drugs called norepinephrine serotonin reuptake inhibitors (NSRIs). It is hoped it will be more successful in treating fibromyalgia, said lead investigator Dr. Daniel Clauw, director of the University of Michigan's Chronic Pain and Fatigue Research Program.

    In the study, 125 volunteers were randomly assigned to take an inactive placebo or milnacipran once or twice daily. The participants had fibromyalgia for 5 to 7 years on average, said Clauw.

    Patients who received the twice-daily dose had a statistically significant improvement in pain. Thirty-seven percent reported at least a 50 percent reduction in pain intensity compared with 14 percent of placebo patients. Seventy percent of all milnacipran-treated patients reported overall improvement compared with 36 percent of placebo patients.

    The most commonly reported side effect was nausea. About 27 percent of volunteers dropped out of the study, but that was no higher than expected, said Clauw, who presented the results at the annual meeting of the American Pain Society.

    Cypress Bioscience Inc., based in San Diego, California, licensed the North American rights to the drug from France's bioMerieux Pierre Fabre in August 2001.

    With the promising results in hand, Cypress hopes to begin phase III studies late this year, said Clauw, who is also chairman of Cypress' Rheumatology Advisory Board, and has a interest -- financially and scientifically -- in seeing milnacipran receive U.S. Food and Drug Administration approval.

    LITEFLAMES New Member

    hi mel read you"r post what is zma???
  3. Mikie

    Mikie Moderator

    Whether an NSRI damages the brain as do the SSRI's, according to Dr. Cheney. I am glad there is research to help those for whom other treatments do not work, but I do not like to take meds until they have been on the market at least five years.

    Mel, I agree that the ZMA helps tremendously with pain, but now it appears that the Klonopin may also help by disrupting the pain signals in the brain. Your ZMA may be working synergistically with the Klonopin to help with the pain. ZMA seems to enchance the other meds we take.

    Love, Mikie
  4. Achy-shaky

    Achy-shaky New Member

    I'm really happy for those of you who can take zma and afford it. Living on a fixed income doesnt allow for many supplements, have to pay rent and buy food first. when it's paid by insurance then I'll be happy to try it!!!