Severe Discontinuation Syndrome Venlafaxine is notorious for its severe withdrawal symptoms upon discontinuation. These effects may include severe fatigue, dysphoria, irritability, hostility, headache, nausea, vertigo, dizziness and paresthesia. Other non-specific mental symptoms may include; impaired concentration, bizarre dreams, agitation and suicidal thoughts. The fairly-unique "brain shivers" have been described as electric-like shocks in the brain causing pounding headaches and disorientation, increasing over time before abating. Although "brain shivers" are not painful per se, they are disturbing, and could become severe enough to be disabling. These withdrawl symptoms are significantly stronger than the withdrawal effects of other antidepressants but are similar in nature to Paroxetine (called Paxil® in the U.S. or Seroxat® in the U.K.). Studies by Wyeth-Ayerst and others have reported occasional cases of withdrawal symptoms severe enough to require permanent use. In some of these cases, successful discontinuation was eventually achieved by the addition of fluoxetine, which was later discontinued itself without difficulty. A Lawsuit was filed by Patel Carolina & Associates PLLC in 2004 due to the discontinuation side effects of the drug.