Elderberry and Olive leaf Extract for CFIDS

Discussion in 'Fibromyalgia Main Forum' started by karynwolfe, Jan 28, 2010.

  1. karynwolfe

    karynwolfe New Member

    ***ARTICLE 1*** (Source: http://www.ncbi.nlm.nih.gov/pubmed/11366542 )

    "AIDS: Elderberry, chondroitin, and glucosamine sulfate have been found to block HIV replication at three distinct points in the replication cycle.

    For quadruple therapy, a reverse transcriptase inhibitor such as olive leaf extract or Epivir (3TC) could be added.

    In one case, a female, taking no HIV drugs, used an elderberry extract, called Sambucol, with olive leaf extract and experienced a viral load drop from 17,000 to 4,000. Instructions are given for making both alcohol-free and alcohol-based elderberry extracts.

    In 1993, researchers at Jerusalem's Hebrew University Medical School found in a placebo-controlled double-blind study that Sambucol led to a rapid recovery from influenza and inhibited replication of nine other strains of the flu virus.

    A theory is that elderberry renders viruses nonfunctional by staining and coating them.
    Another promising treatment is soil based organisms, which improved Natural Killer cell function in a person with CFIDS."

    ***ARTICLE 2*** (Source: http://www.ncbi.nlm.nih.gov/pubmed/12878215 )

    "We investigated the antiviral activity of olive leaf extract (OLE) preparations standardized by liquid chromatography-coupled mass spectrometry (LC-MS) against HIV-1 infection and replication. We find that OLE inhibits acute infection and cell-to-cell transmission of HIV-1 as assayed by syncytia formation using uninfected MT2 cells co-cultured with HIV-1-infected H9 T lymphocytes. OLE also inhibits HIV-1 replication as assayed by p24 expression in infected H9 cells. These anti-HIV effects of OLE are dose dependent, with EC(50)s of around 0.2 microg/ml. In the effective dose range, no cytotoxicity on uninfected target cells was detected. The therapeutic index of OLE is above 5000. To identify viral and host targets for OLE, we characterized gene expression profiles associated with HIV-1 infection and OLE treatment using cDNA microarrays. HIV-1 infection modulates the expression patterns of cellular genes involved in apoptosis, stress, cytokine, protein kinase C, and hedgehog signaling. HIV-1 infection up-regulates the expression of the heat-shock proteins hsp27 and hsp90, the DNA damage inducible transcript 1 gadd45, the p53-binding protein mdm2, and the hedgehog signal protein patched 1, while it down-regulates the expression of the anti-apoptotic BCL2-associated X protein Bax. Treatment with OLE reverses many of these HIV-1 infection-associated changes. Treatment of HIV-1-infected cells with OLE also up-regulates the expression of the apoptosis inhibitor proteins IAP1 and 2, as well as the calcium and protein kinase C pathway signaling molecules IL-2, IL-2Ralpha, and ornithine decarboxylase ODC1."

    ...I can summarize that by saying, basically, olive leaf extract reversed a lot of what the HIV was doing to the gene expression in infected patients.

    I can attest to the olive leaf extract being a huge help--not a cure--because I've been on it for a long while and know of others who've had great success, even with such a serious illness. But do not take my word for it: DO YOUR OWN RESEARCH and you will be impressed with what you find on this herb. =)