On another thread you wrote: L-Tryptophan or 5-HTP,,,, 10/09/06 03:47 PM TwinMa-First, if you are using an SSRI, or MAO inhibitor, you do NOT want to use L-Tryptophan. I use a low dose Doxepin, with my Tryptophan, but that was researched and cleared by my doctor. L-Tryptophan MUST be taken with B-6. I am unable to convert B-6 to the active form, so I must take P5P. Take a small dose, with your L-Tryptophan, a little before you want to go to sleep. I take 25 mg. P5P, with 1500 mg. L-Tryptophan. Generally, you take 500 mg. L-Tryptophan for every 50 lbs. of body weight. The math says I should take more, but the 1500 mg. works for me. It would be good to take a B-Complex, earlier in the day. Take your Tryptophan AWAY from other protein sources, as the amino acids will compete for uptake in the brain. The B-6 is so conversion to Seratonin happens in the brain, not the intestines. I recently added GABA to my regimen which I find helps even more. Hope this is helpful for you. ---------------------------------------------------------- This is TwinMa writing now. Thank you, elliespad, for the good information on L-tryptophan. I still have a couple of questions. How did you know you could not convert B6 to its active form? Do you think that most people could just take L-Tryptophan with regular B6 instead of P5P? You said you take 25mg P5P. Would it be the same amount of regular B6? Do you think most brands of L-Tryptophan are comparable? I'm looking at Source Naturals and Nutraceutical Sciences Institute. Also, do you think there is a difference between the capsules and tablets? Source Naturals sells both forms. Do you take the GABA as well as the L-tryptophan? What does that do for you? Thank you so much for your help. I know you are the "resident expert" on L-tryptophan, and I appreciate your sharing your knowledge.