ENDOMETRIOSIS LINKED TO AUTOIMMUNE....-Article

Discussion in 'Fibromyalgia Main Forum' started by COOKIEMONSTER, Jun 18, 2003.

  1. COOKIEMONSTER

    COOKIEMONSTER New Member

    Endometriosis Linked to Autoimmune and Other Chronic Diseases Including Chronic Fatigue Syndrome & Fibromyalgia
    05-07-2003

    By Laurie Barclay, M.D.
    A cross-sectional survey reported in the Sept. 27 (2002) issue of Human Reproduction showed that women with endometriosis have higher rates of autoimmune and other chronic diseases than do women in the general U.S. population.

    "Women with endometriosis frequently suffer from autoimmune inflammatory diseases, hypothyroidism, fibromyalgia (FM), chronic fatigue syndrome (CFS), allergies and asthma," lead author Ninet Sinaii, from the National Institute of Child Health and Human Development in Bethesda, Maryland, says in a news release. "These findings also suggest a strong association between endometriosis and autoimmune disorders and indicate the need to consider the co-existence of other conditions in women with endometriosis."

    In this population-based survey of 3,680 members of the Endometriosis Association, all had surgically diagnosed endometriosis, 90% were of reproductive age, 66% had a positive family history for diagnosed or suspected endometriosis, and 20% had more than one other chronic disease. Nearly one-third of those with coexisting diseases also had been diagnosed with either FM or CFS, and some of these women also had other autoimmune or endocrine disease.

    Compared with expected rates in the general population of U.S. women, women in this survey had increased rates of chronic disease. CFS was more than a hundred times more common (4.60% vs. 0.03%, P<.0001), hypothyroidism seven times more common (9.6% vs. 1.5%, P<.0001), and FM was nearly twice as common (5.9% vs. 3.4%, P<.0001).

    Women with endometriosis also had higher than expected rates of autoimmune inflammatory diseases including systemic lupus erythematosus, Sjögren's syndrome, and rheumatoid arthritis, as well as multiple sclerosis. Allergies occurred in 61% (vs. 18%; P<.001) and asthma in 12% (vs. 5%; P<.001) of survey subjects overall. Of those subjects who also had FM or CFS, 88% had allergies (P<.001) and 25% had asthma (P<.001).

    "As well as finding an increased prevalence of this wide range of diseases and conditions among women with endometriosis, we found that they reported significant pain and disability and, very worryingly, that there was typically a 10-year delay between the onset of pelvic pain and diagnosis," Sinaii says.

    Potential study limitations included the subjects being relatively young, predominantly white, well-educated, and members of a support group. However, sensitivity analysis confirmed that even if chronic disease prevalence rates were underestimated in the general population and overestimated in the survey, the rates reported in women with endometriosis were still significantly higher.

    "Since women appear to develop symptoms shortly after the onset of their periods and are not diagnosed for years, we don't know whether endometriosis actually occurs at menarche as others have reported or whether it develops over time," senior author Pamela Stratton says. "It's also unclear whether early treatment could prevent chronic pelvic pain from taking hold. It is vital therefore that attempts should be made to diagnose and treat endometriosis in adolescents."

  2. tiredTina

    tiredTina New Member

    Thank you for posting this article, it is very interesting. I was never officially diagnosed with endometriosis, but it was always suspected. I think it's just amazing that all of these things are somehow related and intertwined. Thanks again for the info.
    ~Tina~
  3. judywhit

    judywhit New Member

    have had several lazer surgerys for this. thanks for the article.
    Judy
  4. marecee58

    marecee58 New Member

    Severe Endo diagnosis, finally after years of excruitating pain. Had a hysterectomy 6 years ago and was pain free from the endo within one year of surgery. FMS/CFS symptoms surfaced about 3 years ago and has gotten progressively worse. Seems that if you have one auto-immune disease its likely to have others as well. Certainly something the medical profession "?" should take a closer look at.