Evidence of dysfunctional pain inhibition in Fibromyalgia

Discussion in 'Fibromyalgia Main Forum' started by Bluebottle, May 9, 2009.

  1. Bluebottle

    Bluebottle New Member

    Evidence of dysfunctional pain inhibition in Fibromyalgia reflected
    in rACC during provoked pain.

    Pain. 2009 Apr 30.

    Jensen KB, Kosek E, Petzke F, Carville S, Fransson P, Marcus H,
    Williams SC, Choy E, Giesecke T, Mainguy Y, Gracely R, Ingvar M.

    Stockholm Brain Institute, Osher Center for Integrative Medicine,
    Karolinska Institutet, Stockholm, Sweden.

    PMID: 19410366

    Over the years, many have viewed Fibromyalgia syndrome (FMS) as a
    so-called "functional disorder" and patients have experienced a
    concomitant lack of interest and legitimacy from the medical
    profession. The symptoms have not been explained by peripheral
    mechanisms alone nor by specific central nervous system mechanisms.
    In this study, we objectively evaluated the cerebral response to
    individually calibrated pain provocations of a pain-free body region

    The study comprised 16 female FMS patients and 16 individually
    age-matched controls. Brain activity was measured using functional
    magnetic resonance imaging (fMRI) during individually calibrated
    painful pressures representing 50mm on a visual analogue scale (VAS)
    ranging from 0 to 100mm.

    Patients exhibited higher sensitivity to pain provocation than
    controls as they required less pressure to evoke equal pain
    magnitudes (U(A)=48, p<.002). Despite lower pressures applied in
    patients at VAS 50mm, the fMRI-analysis revealed no difference in
    activity in brain regions relating to attention and affect or regions
    with sensory projections from the stimulated body area. However, in
    the primary link in the descending pain regulating system (the
    rostral anterior cingulate cortex) the patients failed to respond to
    pain provocation. The attenuated response to pain in this brain
    region is the first demonstration of a specific brain region where
    the impairment of pain inhibition in FMS patients is expressed.

    These results validate previous reports of dysfunctional endogenous
    pain inhibition in FMS and advance the understanding of the central
    pathophysiologic mechanisms, providing a new direction for the
    development of successful treatments in FMS.
  2. gapsych

    gapsych New Member

    Thanks for this interesting information. I will copy it and put it in my file on my computer.

    Here's a bump!!!