hi all, i found the following posting on an OCD support board after performing a search on excess histamine. i've always been interested in the role of histamine in our illness(es) since i have days when my histamine levels randomly explode causing hayfever like symptoms even with no elevated allerges reported outside. this is usually after an intense stretching session or a too-deep massage (histamine is released from mast cells on muscles). in any case, i thought this post was interesting even thought the formatting is a little annoying, sorry! for its information of histadelia which is an excess of histamine in the body. eddie ---------------------------------------------------------- I am posting this information on histadelia (histamine high) in an > effort to increase awareness of its existence. Many cases of OCD and > depression are misdiagnosed histadelia (root cause), and there is very > limited information and awareness about it on the internet (a mere 13 > hits on google groups and 73 on google search!). > > Don't let the talk of schizophrenia scare you off -- you don't have to > be schizophrenic to be histadelic, that just represents the extreme > cases. In fact, it is believed that Marilyn Monroe was histadelic. > > The following represents information from assorted uncredited sources. > Please do not email me as the above email address is not in use and I > am not a medical professional. > > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- > --- --- --- > > Histadelia (Histamine High) > > Histadelia, more common in males, is characterized by elevated blood > levels of histamine. It is estimated that 15-20% of schizophrenics are > probably histadelic. The treatment of histadelia requires great > patience because six to ten weeks are often needed before the > beginning of significant improvement. The treatment usually takes > twelve months to complete. To find out more about this see Mental > Illness: The Nutrition Connection, a book by Carl Pfeiffer. The > prognosis is good if the histadelic patient cooperates with treatment > and works to give up detrimental addictions. > > > *** Signs, symptoms & indicators of Histadelia (Histamine High): > > * Allergy > > * Excess mucous: Histamine can cause additional mucus production. > > * Good tolerance of cold > > * Poor tolerance of heat > > * Unexplained nausea > > * Poor pain tolerance > > * Excess/abundant saliva in mouth > > * Hyperactivity: Histamine speeds up metabolism producing a > tendency towards hyperactivity. > > * Frequent colds/flus > > * Phobias > > * Being highly motivated: Those with elevated histamine > (histadelics) tend to work compulsively. > > * A hard-driving personality: Histadelics tend to work > compulsively. > > * Good creativity/imagination: Histadelics are often highly > creative. > > * Strong sexual desire > > * Joint pain/swelling/stiffness > > * Excess perspiration > > * Warm skin > > > *** Conditions that suggest Histadelia (Histamine High): > > * Allergy: Allergic Rhinitis / Hay Fever > > * Depression: Histadelics are often chronically and suicidally > depressed. > > * Obsessive-Compulsive Disorder (OCD): Histadelics are often prone > to obsessions, compulsions, and addictions. > > * Addictions / Addictive Tendencies: Nutritional treatment for drug > and alcohol users will depend on the results of a test for blood > histamine levels. In one series of such analysis, all users proved to > have high histamine levels, leading the scientist to conclude that > this abnormality - with its impact on brain function - is a major > force in creating addiction. [Nutrition Guide for the Prevention and > Cure of Common Ailments and Diseases, Carlton Fredericks, PhD. p.58] > > * Headaches > > * Insomnia: The overarousal seen in histadelia may contribute to > insomnia. > > * Muscle Pains (Myalgia) > > * History of unexplained nausea > > * Slender fingers / toes: Histadelics often have long fingers and > toes. > > > *** Recommendations for Histadelia (Histamine High): > > * Methionine: Methionine supplements lower blood levels of > histamine by increasing histamine breakdown. > > * Calcium > > * Copper: Copper levels may be low to normal in patients with > histadelia. Copper is part of the enzyme histaminase, which is > involved in the metabolism of histamine. > > * Magnesium > > * Manganese > > * Vitamin B6 (Pyridoxine) > > * Vitamin C (Ascorbic Acid) > > * Vegetarian/Vegan Diet Nutritionists recommend a low-protein, high > complex carbohydrate diet. Histidine, which is more common in animal > proteins, should be avoided as it can be converted into histamine. > > > *** Not recommended > > * Vitamin Folic Acid: Histadelics should avoid supplemental folic > acid as it can produce excess histamine. In fact, anti-folate drugs > may be required. Folic acid increases depression in histadelic > patients and a trial of folic acid could be used to distinguish > between histapenics and histadelics. In extreme cases, folic acid in > food or in multivitamins is enough to produce the adverse effects. > > > *** Lab Tests > > * Copper Levels: Testing serum or hair copper levels is usually > adequate for evaluating copper status when low levels of copper are > suspected and hair contamination with copper can be ruled out. When in > doubt, it would be better to use more accurate tests such as the 24 > hour urine copper or serum ceruloplasmin. > > * Histamine Levels > > * Folic Acid Levels: Under certain conditions, such as anticipated > or actual pregnancy, a simple lab test for serum folate levels is > advisable. If the test results show low levels, supplementation should > be considered to prevent potential birth defects. > > * Zinc Levels > > * Manganese Levels > > > *** Glossary > > * Histamine: A chemical in the body tissues, produced by the > breakdown of histidine. It is released in allergic reactions and > causes widening of capillaries, decreased blood pressure, increased > release of gastric juice, fluid leakage forming itchy skin and hives, > and tightening of smooth muscles of the bronchial tube and uterus. > > * Metabolism: The chemical processes of living cells in which energy > is produced in order to replace and repair tissues and maintain a > healthy body. Responsible for the production of energy, biosynthesis > of important substances, and degradation of various compounds. > > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- > --- --- --- > > Histadelia represents the chemical antithesis of histapenia in that it > involves elevated blood histamine. This condition (involving about 20 > percent of schizophrenics) is characterized by delusions, severe > depression, obsessive/compulsive behavior, and blank-mindedness, and > often results in a diagnosis of schizo-affective disorder. Treatment > revolves around anti-folates such as calcium, methionine, and the > prescription drug Dilantin® along with augmenting nutrients. > Histadelia treatment requires great patience, because six to ten weeks > are often needed before the beginning of significant improvement. The > treatment usually takes twelve months to complete. > > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- > --- --- --- > > Histadelic depressives have a particular imbalanced amino-acid cycle, > which results in low levels of serotonin and elevated histamine. > Histadelics often exhibit obsessive-compulsive tendencies, > perfectionism, seasonal allergies, easy tears, high libido, and > headaches. They have addictive tendencies with a high incidence of > alcoholism, drug abuse, anorexia, and bulimia. They often are > diagnosed with seasonal affective disorder which is most serious > during Fall and Winter. The decisive chemical test for this condition > is whole blood histamine. We treat histadelia with a biochemical > one-two punch in which (1) calcium is given to release excess > histamine from tissues into the bloodstream, and (2) methionine (SAMe) > is provided to add a methy group to blood histamine and hasten its > exit from the body. With good compliance, improvement is usually noted > in 4-8 weeks with about 3-6 months needed to correct this chemical > imbalance. > > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- > --- --- --- > > Armed with the proper nutrients, I smuggled them back in to the last > hospital I was in, and took them on the sly while mouthing my > medication, and spitting it down a toilet. > > After just three weeks of taking my supplements, I was doing so much > better that I was given a full medical discharge, with the doctors > scratching their heads, wondering which of their drugs had been > helping me, but none of them had been -- I was spitting them all down > the toilet where the toxic substances belonged. That was 23 years ago. > > Pfeiffer discovered that food and inhalant allergies caused me to have > an overproduction of histamine which is peripherally stored in > basophils of the blood and the tissue mast cells. Basophil counts > greater than 50 cells/cu mm and histamine levels greater than 70 ng/ml > (10 mcg%) are considered diagnostic for histadelia. The average > histamine for males was 111 mg/ml and females 107 mg/ml in a study > reported in 1975. My histamine levels were up to 126. This is > significantly different from normals: 42 and 46 mg/ml for males and > females respectively. Histadelia causes suicidal depression, paranoia, > and obsessive thinking. > > The amino acid methionine (SAMe) detoxifies histamine by methylating > the ring structure forming N-methylhistamine. Calcium, taken in the > form of calcium salts reduces the release of the bodies store of > histamine. Zinc and manganese aid the calcium-methionine program and > provide sufficient relief. > > Pfeiffer also discovered that I had very high aluminum levels, and > copper levels, as well as overproduction of an enzyme called > kryptopyrolle. This enzyme robbed me of zinc, a copper antagonist that > I needed to eliminate excess copper which was having an excitory > effect on the brain as an electrolyte, contributing to my difficulty > concentrating, to thought disorder as well as to my severe depression. > > In essence: high copper levels were shorting out my brain, interfering > with neural firing. Zinc, Manganese, and vitamin C all help to lower a > copper burden. The amino acids l-tyrosine, and l-tryptophan boost > norepeniphrine and dopamine levels respectively, also helping to > alleviate depression. > > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- > --- --- --- > > Histadelia: This is a disorder, prominent in males, of too much > histamine in the blood. Estimated to affect 15-20% of patients > classified as "schizophrenic." > > Symptoms include hyperactivity, compulsions, obsessions, inner > tensions, blank mind episodes, phobias, chronic depression, and strong > suicidal tendencies. > > Physical signs can include little tolerance for pain, rapid > metabolism, lean build, profuse sweating, seasonal allergies, and > frequent colds. > > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- > --- --- --- > > Histadelia - In the early years of this century, at the height of his > career, Nijinski, the much-acclaimed Russian dancer, was diagnosed as > incurably insane. Nijinsky may have been histadelic. One of the first > indications of his illness occurred when Nijinsky, who had previously > been especially caring and gentle, pushed his wife and infant child > downstairs and afterwards seemed confused about the incident. He began > refusing animal food (actually, probably a beneficial choice, if he > was histadelic), and sometimes would not eat at all for long periods > of time. He became obsessed with recurrent visions of dead soldiers, > and prone to violence, especially when separated from the mental > institute. Nijinsky never recovered and never danced again, although > his wife found that he did not seem to have forgotten any move of any > dance he ever performed. > > Histadelia is characterized by elevated blood levels of histamine. > 15-20% of schizophrenics are probably histadelic. Histadelics tend to > work compulsively and are often highly creative. On the other hand, > they are often chronically and suicidally depressed and prey to > obsessions, compulsions, and addictions. > > Typical treatment includes such nutrients as calcium, magnesium, B6, > C, zinc, manganese, and methionine (SAMe), and limitation of intake of > folic acid and histidine (common in animal proteins). If the > histadelic cooperates with treatment and works to give up detrimental > addictions, the prognosis is good. > > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- > --- --- --- > > On the physical front, nutrient deficiencies, glucose intolerance and > allergy are extremely common in those suffering from depression. One > major cause is an excess of the neurotransmitter hormone histamine - a > condition known as histadelia. Dr Carl Pfeiffer asks: "Do you sneeze > in bright sunlight? Cry, salivate and feel nauseous easily? Hear your > pulse in your head on the pillow at night? Have frequent backaches, > stomach and muscle cramps? Do you have regular headaches and seasonal > allergies? Have abnormal fears, compulsions and rituals? Do you burn > up food rapidly and sometimes entertain suicidal thoughts? ...If a > majority of these apply to you, you may benefit from a low-protein, > high complex carbohydrate diet (fruits and vegetables), 500mg of > calcium, am and pm, 500mg methionine am and pm and a basic supplement > program. Avoid supplements containing folic acid as these can raise > histamine levels." > > Some of our most loved stars, such as Marilyn Monroe and Judy Garland, > were likely histadelics. Drawing from over 30 years' experience, > Pfeiffer estimates that at least 20% of schizophrenics are histadelics > and these are often the problem patients in psychiatric hospitals, > since they do not respond to the usual drug treatments, electroshock > or insulin coma 'therapy'. > > Blood histamine levels can be analysed and often, the compulsive > obsessions, blank mind, easy crying and confusion may highlight an > underlying chemical addiction to cane sugar, alcohol or drugs. > Histadelics experience high saliva discharge and rarely have cavities. > Often they are seen wiping saliva from the corners of their mouth. > Excess histamine presents rapid oxidation in their body, and their > high metabolic rate and subsequent attractive body shape are sometimes > potential indicators for the underlying condition. Marilyn Monroe was > often heard to remark to photographers: "You always take pictures of > my body, but my most perfect feature is my teeth - I have no > cavities." > > A high sex drive characterises the histadelic, who achieves orgasm and > sustains it easily. Drug addicts and alcoholics also tend to be > histadelic. Heroin and methadone for instance are both powerful > histamine-releasing agents. A severe insomnia also characterises the > condition, and sufferers often use heavy doses of sedatives in order > to get to sleep. The sedatives themselves often become an addiction > problem, further compounding the plight suffered by those with > depression. > > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- > --- --- --- > > A common contributory cause of depression is an excess of histamine, > known as histadelia, which is mostly inherited. Histamine speeds up > metabolism but also causes allergic reactions, increased mucus and > saliva production and a tendency to hyperactivity, compulsive > behaviour and depression. About 20% of those labelled schizophrenic > and most depressed people are histadelic. Some of the signs of this > tendency are insomnia, frequent headaches, body aches, salivation and > nausea. > > To find out more about this consult a nutritionist or see Mental > Illness: The Nutrition Connection, a book by Carl Pfeiffer. > > Ways to overcome histadelia: Nutritionists recommend a low-protein, > high complex carbohydrate diet. That means replacing refined > carbohydrates in things like chocolate, snacks and white bread with > unrefined carbohydrates in wholefoods and grains, fruit and > vegetables, including potatoes. Histadelics should avoid folic acid, > as it can produce excess histamine. Folic acid comes in many > multivitamin pills, and also certain vegetables such as spinach, > lettuce and broccoli. It is also found in liver and kidneys.