Excess Histamine - Histadelia - Anyone heard of this?

Discussion in 'Fibromyalgia Main Forum' started by bpmwriter, Jan 20, 2006.

  1. bpmwriter

    bpmwriter New Member

    hi all,

    i found the following posting on an OCD support board after performing a search on excess histamine. i've always been interested in the role of histamine in our illness(es) since i have days when my histamine levels randomly explode causing hayfever like symptoms even with no elevated allerges reported outside. this is usually after an intense stretching session or a too-deep massage (histamine is released from mast cells on muscles). in any case, i thought this post was interesting even thought the formatting is a little annoying, sorry! for its information of histadelia which is an excess of histamine in the body.



    I am posting this information on histadelia (histamine high) in an
    > effort to increase awareness of its existence. Many cases of OCD and
    > depression are misdiagnosed histadelia (root cause), and there is very
    > limited information and awareness about it on the internet (a mere 13
    > hits on google groups and 73 on google search!).
    > Don't let the talk of schizophrenia scare you off -- you don't have to
    > be schizophrenic to be histadelic, that just represents the extreme
    > cases. In fact, it is believed that Marilyn Monroe was histadelic.
    > The following represents information from assorted uncredited sources.
    > Please do not email me as the above email address is not in use and I
    > am not a medical professional.
    > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
    > --- --- ---
    > Histadelia (Histamine High)
    > Histadelia, more common in males, is characterized by elevated blood
    > levels of histamine. It is estimated that 15-20% of schizophrenics are
    > probably histadelic. The treatment of histadelia requires great
    > patience because six to ten weeks are often needed before the
    > beginning of significant improvement. The treatment usually takes
    > twelve months to complete. To find out more about this see Mental
    > Illness: The Nutrition Connection, a book by Carl Pfeiffer. The
    > prognosis is good if the histadelic patient cooperates with treatment
    > and works to give up detrimental addictions.
    > *** Signs, symptoms & indicators of Histadelia (Histamine High):
    > * Allergy
    > * Excess mucous: Histamine can cause additional mucus production.
    > * Good tolerance of cold
    > * Poor tolerance of heat
    > * Unexplained nausea
    > * Poor pain tolerance
    > * Excess/abundant saliva in mouth
    > * Hyperactivity: Histamine speeds up metabolism producing a
    > tendency towards hyperactivity.
    > * Frequent colds/flus
    > * Phobias
    > * Being highly motivated: Those with elevated histamine
    > (histadelics) tend to work compulsively.
    > * A hard-driving personality: Histadelics tend to work
    > compulsively.
    > * Good creativity/imagination: Histadelics are often highly
    > creative.
    > * Strong sexual desire
    > * Joint pain/swelling/stiffness
    > * Excess perspiration
    > * Warm skin
    > *** Conditions that suggest Histadelia (Histamine High):
    > * Allergy: Allergic Rhinitis / Hay Fever
    > * Depression: Histadelics are often chronically and suicidally
    > depressed.
    > * Obsessive-Compulsive Disorder (OCD): Histadelics are often prone
    > to obsessions, compulsions, and addictions.
    > * Addictions / Addictive Tendencies: Nutritional treatment for drug
    > and alcohol users will depend on the results of a test for blood
    > histamine levels. In one series of such analysis, all users proved to
    > have high histamine levels, leading the scientist to conclude that
    > this abnormality - with its impact on brain function - is a major
    > force in creating addiction. [Nutrition Guide for the Prevention and
    > Cure of Common Ailments and Diseases, Carlton Fredericks, PhD. p.58]
    > * Headaches
    > * Insomnia: The overarousal seen in histadelia may contribute to
    > insomnia.
    > * Muscle Pains (Myalgia)
    > * History of unexplained nausea
    > * Slender fingers / toes: Histadelics often have long fingers and
    > toes.
    > *** Recommendations for Histadelia (Histamine High):
    > * Methionine: Methionine supplements lower blood levels of
    > histamine by increasing histamine breakdown.
    > * Calcium
    > * Copper: Copper levels may be low to normal in patients with
    > histadelia. Copper is part of the enzyme histaminase, which is
    > involved in the metabolism of histamine.
    > * Magnesium
    > * Manganese
    > * Vitamin B6 (Pyridoxine)
    > * Vitamin C (Ascorbic Acid)
    > * Vegetarian/Vegan Diet Nutritionists recommend a low-protein, high
    > complex carbohydrate diet. Histidine, which is more common in animal
    > proteins, should be avoided as it can be converted into histamine.
    > *** Not recommended
    > * Vitamin Folic Acid: Histadelics should avoid supplemental folic
    > acid as it can produce excess histamine. In fact, anti-folate drugs
    > may be required. Folic acid increases depression in histadelic
    > patients and a trial of folic acid could be used to distinguish
    > between histapenics and histadelics. In extreme cases, folic acid in
    > food or in multivitamins is enough to produce the adverse effects.
    > *** Lab Tests
    > * Copper Levels: Testing serum or hair copper levels is usually
    > adequate for evaluating copper status when low levels of copper are
    > suspected and hair contamination with copper can be ruled out. When in
    > doubt, it would be better to use more accurate tests such as the 24
    > hour urine copper or serum ceruloplasmin.
    > * Histamine Levels
    > * Folic Acid Levels: Under certain conditions, such as anticipated
    > or actual pregnancy, a simple lab test for serum folate levels is
    > advisable. If the test results show low levels, supplementation should
    > be considered to prevent potential birth defects.
    > * Zinc Levels
    > * Manganese Levels
    > *** Glossary
    > * Histamine: A chemical in the body tissues, produced by the
    > breakdown of histidine. It is released in allergic reactions and
    > causes widening of capillaries, decreased blood pressure, increased
    > release of gastric juice, fluid leakage forming itchy skin and hives,
    > and tightening of smooth muscles of the bronchial tube and uterus.
    > * Metabolism: The chemical processes of living cells in which energy
    > is produced in order to replace and repair tissues and maintain a
    > healthy body. Responsible for the production of energy, biosynthesis
    > of important substances, and degradation of various compounds.
    > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
    > --- --- ---
    > Histadelia represents the chemical antithesis of histapenia in that it
    > involves elevated blood histamine. This condition (involving about 20
    > percent of schizophrenics) is characterized by delusions, severe
    > depression, obsessive/compulsive behavior, and blank-mindedness, and
    > often results in a diagnosis of schizo-affective disorder. Treatment
    > revolves around anti-folates such as calcium, methionine, and the
    > prescription drug Dilantin® along with augmenting nutrients.
    > Histadelia treatment requires great patience, because six to ten weeks
    > are often needed before the beginning of significant improvement. The
    > treatment usually takes twelve months to complete.
    > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
    > --- --- ---
    > Histadelic depressives have a particular imbalanced amino-acid cycle,
    > which results in low levels of serotonin and elevated histamine.
    > Histadelics often exhibit obsessive-compulsive tendencies,
    > perfectionism, seasonal allergies, easy tears, high libido, and
    > headaches. They have addictive tendencies with a high incidence of
    > alcoholism, drug abuse, anorexia, and bulimia. They often are
    > diagnosed with seasonal affective disorder which is most serious
    > during Fall and Winter. The decisive chemical test for this condition
    > is whole blood histamine. We treat histadelia with a biochemical
    > one-two punch in which (1) calcium is given to release excess
    > histamine from tissues into the bloodstream, and (2) methionine (SAMe)
    > is provided to add a methy group to blood histamine and hasten its
    > exit from the body. With good compliance, improvement is usually noted
    > in 4-8 weeks with about 3-6 months needed to correct this chemical
    > imbalance.
    > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
    > --- --- ---
    > Armed with the proper nutrients, I smuggled them back in to the last
    > hospital I was in, and took them on the sly while mouthing my
    > medication, and spitting it down a toilet.
    > After just three weeks of taking my supplements, I was doing so much
    > better that I was given a full medical discharge, with the doctors
    > scratching their heads, wondering which of their drugs had been
    > helping me, but none of them had been -- I was spitting them all down
    > the toilet where the toxic substances belonged. That was 23 years ago.
    > Pfeiffer discovered that food and inhalant allergies caused me to have
    > an overproduction of histamine which is peripherally stored in
    > basophils of the blood and the tissue mast cells. Basophil counts
    > greater than 50 cells/cu mm and histamine levels greater than 70 ng/ml
    > (10 mcg%) are considered diagnostic for histadelia. The average
    > histamine for males was 111 mg/ml and females 107 mg/ml in a study
    > reported in 1975. My histamine levels were up to 126. This is
    > significantly different from normals: 42 and 46 mg/ml for males and
    > females respectively. Histadelia causes suicidal depression, paranoia,
    > and obsessive thinking.
    > The amino acid methionine (SAMe) detoxifies histamine by methylating
    > the ring structure forming N-methylhistamine. Calcium, taken in the
    > form of calcium salts reduces the release of the bodies store of
    > histamine. Zinc and manganese aid the calcium-methionine program and
    > provide sufficient relief.
    > Pfeiffer also discovered that I had very high aluminum levels, and
    > copper levels, as well as overproduction of an enzyme called
    > kryptopyrolle. This enzyme robbed me of zinc, a copper antagonist that
    > I needed to eliminate excess copper which was having an excitory
    > effect on the brain as an electrolyte, contributing to my difficulty
    > concentrating, to thought disorder as well as to my severe depression.
    > In essence: high copper levels were shorting out my brain, interfering
    > with neural firing. Zinc, Manganese, and vitamin C all help to lower a
    > copper burden. The amino acids l-tyrosine, and l-tryptophan boost
    > norepeniphrine and dopamine levels respectively, also helping to
    > alleviate depression.
    > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
    > --- --- ---
    > Histadelia: This is a disorder, prominent in males, of too much
    > histamine in the blood. Estimated to affect 15-20% of patients
    > classified as "schizophrenic."
    > Symptoms include hyperactivity, compulsions, obsessions, inner
    > tensions, blank mind episodes, phobias, chronic depression, and strong
    > suicidal tendencies.
    > Physical signs can include little tolerance for pain, rapid
    > metabolism, lean build, profuse sweating, seasonal allergies, and
    > frequent colds.
    > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
    > --- --- ---
    > Histadelia - In the early years of this century, at the height of his
    > career, Nijinski, the much-acclaimed Russian dancer, was diagnosed as
    > incurably insane. Nijinsky may have been histadelic. One of the first
    > indications of his illness occurred when Nijinsky, who had previously
    > been especially caring and gentle, pushed his wife and infant child
    > downstairs and afterwards seemed confused about the incident. He began
    > refusing animal food (actually, probably a beneficial choice, if he
    > was histadelic), and sometimes would not eat at all for long periods
    > of time. He became obsessed with recurrent visions of dead soldiers,
    > and prone to violence, especially when separated from the mental
    > institute. Nijinsky never recovered and never danced again, although
    > his wife found that he did not seem to have forgotten any move of any
    > dance he ever performed.
    > Histadelia is characterized by elevated blood levels of histamine.
    > 15-20% of schizophrenics are probably histadelic. Histadelics tend to
    > work compulsively and are often highly creative. On the other hand,
    > they are often chronically and suicidally depressed and prey to
    > obsessions, compulsions, and addictions.
    > Typical treatment includes such nutrients as calcium, magnesium, B6,
    > C, zinc, manganese, and methionine (SAMe), and limitation of intake of
    > folic acid and histidine (common in animal proteins). If the
    > histadelic cooperates with treatment and works to give up detrimental
    > addictions, the prognosis is good.
    > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
    > --- --- ---
    > On the physical front, nutrient deficiencies, glucose intolerance and
    > allergy are extremely common in those suffering from depression. One
    > major cause is an excess of the neurotransmitter hormone histamine - a
    > condition known as histadelia. Dr Carl Pfeiffer asks: "Do you sneeze
    > in bright sunlight? Cry, salivate and feel nauseous easily? Hear your
    > pulse in your head on the pillow at night? Have frequent backaches,
    > stomach and muscle cramps? Do you have regular headaches and seasonal
    > allergies? Have abnormal fears, compulsions and rituals? Do you burn
    > up food rapidly and sometimes entertain suicidal thoughts? ...If a
    > majority of these apply to you, you may benefit from a low-protein,
    > high complex carbohydrate diet (fruits and vegetables), 500mg of
    > calcium, am and pm, 500mg methionine am and pm and a basic supplement
    > program. Avoid supplements containing folic acid as these can raise
    > histamine levels."
    > Some of our most loved stars, such as Marilyn Monroe and Judy Garland,
    > were likely histadelics. Drawing from over 30 years' experience,
    > Pfeiffer estimates that at least 20% of schizophrenics are histadelics
    > and these are often the problem patients in psychiatric hospitals,
    > since they do not respond to the usual drug treatments, electroshock
    > or insulin coma 'therapy'.
    > Blood histamine levels can be analysed and often, the compulsive
    > obsessions, blank mind, easy crying and confusion may highlight an
    > underlying chemical addiction to cane sugar, alcohol or drugs.
    > Histadelics experience high saliva discharge and rarely have cavities.
    > Often they are seen wiping saliva from the corners of their mouth.
    > Excess histamine presents rapid oxidation in their body, and their
    > high metabolic rate and subsequent attractive body shape are sometimes
    > potential indicators for the underlying condition. Marilyn Monroe was
    > often heard to remark to photographers: "You always take pictures of
    > my body, but my most perfect feature is my teeth - I have no
    > cavities."
    > A high sex drive characterises the histadelic, who achieves orgasm and
    > sustains it easily. Drug addicts and alcoholics also tend to be
    > histadelic. Heroin and methadone for instance are both powerful
    > histamine-releasing agents. A severe insomnia also characterises the
    > condition, and sufferers often use heavy doses of sedatives in order
    > to get to sleep. The sedatives themselves often become an addiction
    > problem, further compounding the plight suffered by those with
    > depression.
    > --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
    > --- --- ---
    > A common contributory cause of depression is an excess of histamine,
    > known as histadelia, which is mostly inherited. Histamine speeds up
    > metabolism but also causes allergic reactions, increased mucus and
    > saliva production and a tendency to hyperactivity, compulsive
    > behaviour and depression. About 20% of those labelled schizophrenic
    > and most depressed people are histadelic. Some of the signs of this
    > tendency are insomnia, frequent headaches, body aches, salivation and
    > nausea.
    > To find out more about this consult a nutritionist or see Mental
    > Illness: The Nutrition Connection, a book by Carl Pfeiffer.
    > Ways to overcome histadelia: Nutritionists recommend a low-protein,
    > high complex carbohydrate diet. That means replacing refined
    > carbohydrates in things like chocolate, snacks and white bread with
    > unrefined carbohydrates in wholefoods and grains, fruit and
    > vegetables, including potatoes. Histadelics should avoid folic acid,
    > as it can produce excess histamine. Folic acid comes in many
    > multivitamin pills, and also certain vegetables such as spinach,
    > lettuce and broccoli. It is also found in liver and kidneys.
  2. victoria

    victoria New Member


    bumping this up so it doesn't get lost...

  3. xchocoholic

    xchocoholic New Member

    I didn't get a chance to read this whole article, but it reminded me of this website that contains a list of foods that contain histamines. I'm finding that there's a lot we don't know about foods ... Marcia

    <br>[<i>This Message was Edited on 03/24/2008</i>]
  4. tansy

    tansy New Member

    I used to have to avoid many these foods especially when allergy Sx were already present.

    Since being on the the basic methyl supps a while I find I can eat some of these foods again though I don't overdo it just in case.

    tc, Tansy
    <br>[<i>This Message was Edited on 03/24/2008</i>]
  5. evaedelman

    evaedelman New Member

    I have written extensively on histadelia over the past year 2011-12 (and some before that) in my blog:&lt;BR&gt;
    It is full of details and biochemistry. &lt;BR&gt;
    For a broader view, see bipolar: treatments at&lt;BR&gt;
    Feedback and questions welcome!
  6. rockyjs

    rockyjs Member

    I had such high histamines for years that I would get hives in my GI tract from many foods. I couldn't even walk into a room where there were strawberries...it was miserable.&lt;BR&gt;
    In about 1992 I came across a book on amino acids written by an MD in England. He gave several instances of patients being cured of allergies with L-Histidine supplementation. It's a totally paradoxical approach because the amino acid histidine is the foundation for histamines. However the lower your blood level, the more it is converted, so by taking histidine you actually stabilize the mast cells and stop the cycle. &lt;BR&gt;
    I was really nervous about trying it, but I started with very small doses and sure enough, my allergic reactions stopped, my overall inflammation decreased, and I was able to eat foods I hadn't touched in years. It also stopped my chronic IBS. &lt;BR&gt;
    When I was working as a nutritional consultant I suggested that many of my high histamine clients try it and they also saw amazing results. The only thing you have to watch is depletion of zinc. That's pretty easy to detect...your smooth muscles become sluggish causing constipation and your nose gets a bit stuffy. The ratio I suggest is 500 mg histidine and 10 mg zinc. &lt;BR&gt;
    People taking higher doses of zinc and B6 will make more histamines and create higher levels of inflammatory prostaglandins since those nutrients are the co-factors for histidine to histamine conversion. In spite of my risk factors for autoimmune conditions my C reactive protein level is almost zero and so are my other markers like ANA, RA and sed rate. &lt;BR&gt;
    This is a link to a paper I wrote many years ago when I was a personal trainer:&lt;BR&gt;
    It explains a bit more how histidine works to naturally increase cortisol levels. &lt;BR&gt;
    Another very unexpected benefit of taking histidine was it cured my mercury sensitivity. It binds very well with mercury and chelates it out of the body. &lt;BR&gt;
  7. sunflowergirl

    sunflowergirl Well-Known Member

    A most interesting paper and one that I've bookmarked. I have meniers disease and what I've read it can be controlled by keeping down the histimines.&lt;BR&gt;
    As I said on another post, everything works together like a smooth dance of vitamins, minerals and other things I have trouble understanding! LOL