Just wondering what folks' experiences have been with Effexor (XR)? Have CFS with secondary depression, anxiety and sleep disorders. Tried Prozac twice and had a terrible reaction both times (serotonergic syndrome/reaction?). Therefore, I feel somewhat gun shy about trying another anti-depressant. Am also on Seroquel and low dose of Clonazepam (Klonapin) for sleep and anxiety. Was on Paxil for a long time, but gradually eliminated it over two years ago, which was shortly followed by my current major depression and anxiety. So, anyone have any experiences or input regarding Effexor, or anything related to what I just described?