I've had CFS since January 2003 with no positive response to many treatments so far. My rheumatologist just prescribed Plaquenil and has high hopes it will do me some good. I was told it's used to treat Malaria but now has off-label use in people with suspected immune deficiencies. My doctor has treated patients with FM and the beginnings of lupus with this drug and has seen good results in many. Does anyone have personal experience with this drug?