My dr upped my fentynal patch from 25 to 50 mgs, and I had a reaction. My face and neck broke out with tiny bumps and pimples. Not hives, but acne. I went back to the 25 mgs but the acne has not cleared up. I also take percoset for breakthru pain (4xs a day). After reading these boards for about an hour now, I see that if your liver is overloaded, you can break out. I'm also peri-menopausal so I'm wondering confused at what is causing this. One confusing point is I stopped taking tylenol for about 1.5 weeks and there was no change in my skin. I do take Milk Thistle (2 a day). So I'm headed to the store to get additional supplements, acne soap (someone said Clearsil soap really helped them) and the right foods (low-carb diet, more protein right?), my sugar cravings are out of control. If this is hormonal should I be taking anything else? I can't take anything with estrogen, breast cancer in the family. Thanks for anything you can offer.