Fibro Treatment

Discussion in 'Fibromyalgia Main Forum' started by PVLady, May 10, 2006.

  1. PVLady

    PVLady New Member

    I came across the website of a pain treatment clinic here in Los Angeles. Below is what they advise for the treatment of fibro. Some of these drugs I have never heard of such as Anzemet and Zofran. This doctor seems to have quite a protocol for fibro treatment. Just thought this is interesting. (So many regular doctors are reluctant to prescribe pain meds).



    Improving the quality of sleep is a priority. Your doctor

    may prescribe medications such as Xanax, Klonopin, Elavil

    and Trazodone to do just that. Your doctor may also

    prescribe strong painkillers such as Vicodin ES, MS

    Contin or Oxycontin. One of the ways these medications

    give you pain relief is by decreasing the level of

    Substance P in your tissues, joints and spinal fluid. In

    some recent studies, injection or oral administration of

    the serotonin-3 antagonist medication Tropisetron

    significantly reduced pain symptoms in patients with

    fibromyalgia. Medications in the same family as

    Tropisetron such as Dolasetron (Anzemet) and Ondansetron

    (Zofran) are normally used for treatment of chemotherapy

    induced nausea and vomiting. These medications bind to

    serotonin receptors and diminish serotonin induced release

    of substance P from nerve fibers. In other studies,

    injection of steroid (methyl prednisolone acetate) in the

    spinal fluid reduced the levels of a pain transmitter

    called interleukin-8 and produced dramatic and long

    lasting pain relief in patients with nerve pain from

    shingles. It is not yet known if this type of treatment

    may also help patients with fibromyalgia. Anti-

    inflammatory drugs such as Tolmetin may be helpful by

    reducing pain and inflammation but sometimes can irritate

    the stomach and cause heartburn or ulcers. Celebrex and

    Vioxx are a new type of anti-inflammatory drugs called COX-

    2 inhibitors. These drugs are effective and will not

    irritate the stomach. A new technique of injection of

    Botulinum toxin in the painful muscles may relieve muscle

    pain. Botulinum toxin is produced by the bacteria

    Clostridium botulinum, which causes botulism food

    poisoning. The toxin allows muscles that are in spasm to relax.

    The injection is very safe but not widely known and only

    performed by a few doctors. An alternative therapy that

    has helped some patients is Guaifenesin, which is an

    ingredient in many over-the-counter cough medications.

    However do not use Guaifenesin in combination with the

    other ingredients that are found in cough mixtures, as

    these can produce side effects. Guaifenesin must be used

    as a 200 mg pure tablet, which is available over the

    counter or a 600 mg tablet available by prescription.

    Alternative therapy practitioners believe that Guaifenesin

    may help by increasing body levels of serotonin and

    decreasing body levels of phosphate. Excess phosphate

    results in cellular overactivity followed by fatigue.

    There is reported to be an initial worsening of symptoms

    with the onset of Guaifenesin treatment and it may take a

    few months to see an improvement. When you have a flare-

    up, use common sense and do not fight the pain. Put ice or

    heat on your painful joints and muscles and wear your

    brace if you have one. You may rub over-the-counter

    ointments, rubs and sprays such as Eucalypta Mint, Ben-Gay

    or Flex-all 454. A new ointment called Zostrix (Capsaicin)

    may also help painful joints by decreasing the amount of

    substance P, which sends pain signals to the brain.

    Zostrix is the burning ingredient in red-hot chili

    peppers. The ointment itself may give you a funny burning

    sensation that lasts the initial couple of days. Wear

    rubber gloves when you apply it and keep it out of your

    eyes. Rest is important because fatigue can make the pain

    worse. Your doctor may sometimes recommend injections of

    steroid into the painful joints. Pantothenic acid (also

    called Vitamin B5) has been found to decrease inflammation

    and relieve pain in some people. Take 1000 mg daily for

    one month and then reduce to 500 mg daily. Your doctor may

    use biofeedback or meditation to help you learn to relax.

    If you are depressed you may need a higher dose of

    antidepressant medication and counseling.

    Call your Doctor if you experience constipation or any

    side effects from your medications. Inform your doctor

    that you have a right to obtain adequate pain relief.

    National Organization: The Fibromyalgia Network Phone: 1-

    800-853-2929). You may request educational brochures and

    information on classes, clubs, support groups and

    physician referrals..

    Note: All medications mentioned on this site--including,

    specialty compounded ointments such as Capsaicin,

    Gabapentin, Ketamine, Vitamin E--may be ordered directly from L.A. Pain Clinic.