I was finally diagnosed a month ago with Fibromyalgia. I also was diagnosed some time ago with Manic Depression, Bipolar disoder type II/Borderline type I. I stopped taking Lithium two years ago and have been just fine. No relapses. My rheumatologist put me on Flexeril (cyclobenzaprine) one month ago. I take 10mg at night. Within a week I felt all the symptoms of the Fibromyalgia disappear and I felt a tremendous surge in energy! I honestly feel a tiny bit hypomanic, and I honestly like it. Now, Manic Depressives cannot have tricyclic antidepressants, generally speaking, and cyclobenzaprine (Flexeril) is chemically similar to them. My Rheumy was going to put me on Cymbalta, too, but decided not to after researching it. Manic depressives can't have Cymbalta. I've poured over drug abstracts and some of the Bipolar disorder websites to see if there is a contraindication with Manic depression and Flexeril. Haven't found any. See, I said a prayer two years ago and felt I was healed of my Bipolar disorder. I went off Lithum cold turkey and had no ill effects. Also have had no relapses of Manic depression. I feel GOOD on Flexeril---almost so good it worries me. It seems like my reaction to it is somewhat out of proportion to the amount I'm taking. I started a painting, get my housework done ahead of schedule, have gotten caught up on my business paperwork, and have a huge amount of sudden idle time on my hands. I'm happy with it. But I do worry that it might lead to a manic attack. I'm watching myself carefully for Manias. I have told my close friends to also watch for symptoms: pressured speech, strange and grandiose ideas, irrational anger, anxiety, any unusual behavior. My friends say I'm acting normal, so far. In fact, they say I act like my "old self," before my last fibro flare-up that started six months ago. Anyone know anymore info on this? Because Flexeril is chemically related to the tricyclic antidepressants, does it also have antidepressant qualities that might be a danger to someone with a history of Manic Depresson?