FM: oxidative stress and nitric oxide

Discussion in 'Fibromyalgia Main Forum' started by tansy, Dec 6, 2005.

  1. tansy

    tansy New Member

    Current concepts in the pathophysiology of fibromyalgia: the potential role

    Rheumatol Int. 2005 Nov 20;:1-13 [Epub ahead of print]

    Ozgocmen S, Ozyurt H, Sogut S, Akyol O.

    Division of Rheumatology, Department of Physical Medicine and
    Rehabilitation, Faculty of Medicine, Firat University, 23119, Elazig,

    PMID: 16328420

    Fibromyalgia (FM) is a common chronic pain syndrome with an unknown
    etiology. Recent years added new information to our understanding of FM
    pathophysiology. Researches on genetics, biogenic amines,
    neurotransmitters, hypothalamic-pituitary-adrenal axis hormones, oxidative
    stress, and mechanisms of pain modulation, central sensitization, and
    autonomic functions in FM revealed various abnormalities indicating that
    multiple factors and mechanisms are involved in the pathogenesis of FM.

    Oxidative stress and nitric oxide may play an important role in FM
    pathophysiology, however it is still not clear whether oxidative stress
    abnormalities documented in FM are the cause or the effect. This should
    encourage further researches evaluating the potential role of oxidative
    stress and nitric oxide in the pathophysiology of FM and the efficacy of
    antioxidant treatments (omega-3 and -6 fatty acids, vitamins and others) in
    double blind and placebo controlled trials.

    These future researches will enhance our understanding of the complex
    pathophysiology of this disorder.

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