Folic acid can cause a cascading histamine reaction

Discussion in 'Fibromyalgia Main Forum' started by SpiroSpero, Nov 21, 2007.

  1. SpiroSpero

    SpiroSpero New Member

    Hi all!

    Since I have strong problems with folic acid I wanted to show you this interesting abstract I just found. It could be the reason for my problems and I will try some magnesium tomorrow:

    "foods high in folates (folic Acid) should be avoided. folic acid can cause a cascading histamine reaction... Folates are known to cause the release of histamines."

    How severe can histamine reactions be?

    "It has recently been discovered that histamines may play a much larger roll in human disease than once thought. In the past, histamine production was blamed on some very common allergic reactions such as hay fever, bee sting reactions, and anaphylactic shock.

    In recent studies, histamine involvement in chronic inflammatory & degenerative diseases such as lupus, arthritis, Gulf War Syndrome, Fibromyalgia and leaky gut syndrome have been coming to light as to a possible cause of a chronic inflammatory response to abnormal proteins in the blood sera of chronically ill patients!"

  2. kbak

    kbak Member

    for posting this. I went and read the site. Very good info. Learn something new all the time!

  3. Jayna

    Jayna New Member

    I've been taking it for two years for my heart and my allergies in general are better by far than they used to be.

    Also, two of the foods this site recommends, blueberries and sweet potatoes, have more folate in a 100g serving than the minimum daily requirement that is usually included in a B-complex vitamin, while the third food named, bell peppers, contains a whopping 11.5 TIMES as much folate.

    (nutritional information cited here comes from the US Dept of Agriculture's Nutrient Data Laboratory, which has a handy search engine here: )

    A quick search of PubMed for any studies linking folate or folic acid with histamine only turn up research into how folic acid and B12 supplementation are sometimes necessary if a person has suppressed stomach acid. Nothing at all about histamine cascades.

    Not that the lack of a study is definitive, but I'd hate to see people avoiding foods that are basically good for them if they're not noticeably allergic to those food groups and there are no other reliable signs that a histamine cascade is a particular problem of theirs.
    <br>[<i>This Message was Edited on 11/21/2007</i>]
  4. tansy

    tansy New Member

    and other methylation supps too. There were posts a while ago about histamine and supps; but as often happens no clear answers.

    Concern has been expressed recently about taking n acetyl cystiene too.

    Thanks for posting this because even if we do not agree with everythig in any single article it's important we have acccess to what is being written. Knowledge is patient empowerment.

    TC, Tansy

  5. tansy

    tansy New Member

    Folates have numerous roles and one of them is to regulate histamine. Folic acid is one of Marty Pall's recommendations so it should help with Sx related to peroxynitrate.

    My tests showed low serum folate, low RBC folate, and another (loading) test showed I was not metabolising it. So for me Rich's recommendations seem more relevant even though I have had allergic reactions linked to histamine. I was originally treated by one of the orthomolecular medicine pioneers.

    These differences in findings and Tx recommendations highlight why we may need to look into all the possibilities and why we might respond differently to various supps and protocols.

    T <br>[<i>This Message was Edited on 11/21/2007</i>]
  6. SpiroSpero

    SpiroSpero New Member


    Well thanks a lot for your answers. In my eyes folic acid has great advantages and there are so many studies which show the benefits of it. On the other side I'M sure that adverse effects are possible as well. The easiest method to find out is trial and error.

    "Histadelics should avoid supplemental folic acid as it can produce excess histamine. In fact, anti-folate drugs may be required. Folic acid increases depression in histadelic patients and a trial of folic acid could be used to distinguish between histapenics and histadelics. In extreme cases, folic acid in food or in multivitamins is enough to produce the adverse effects."
  7. nixdean

    nixdean New Member

    Hi, I am suffering from high levels of histamine in my body, I have been to a skin allergy specialist and now am on a food restrictive diet ( which helps if I stick to it) and I am taking antihistamine tablets ( texa 10 mg) I just wanted to share my recent experience of Folic Acid...&lt;BR&gt;
    I have recently been told that I should not take any medication as I might be I have stopped taking Texa 10 mg...and started taking Folic Acid supplement...I am so itchy...all over...all the time...Its driving me crazy!&lt;BR&gt;
    But now I have to keep taking Folic Acid ( as it is a neccessary pre natal vitamin)&lt;BR&gt;
    and can't take my anti histamines out of fear that it might cause abnormalities in the baby ..if I am pregnant...&lt;BR&gt;
    Ahhh what to do? &lt;BR&gt;
  8. IanH

    IanH Active Member

    Are you saying that the itchy reactions are at a new level because you are not taking Texa or because you are taking folic acid. Sounds like you usually have atopic allergic reactions.&lt;BR&gt;
    Have you had your vitamin D levels checked? &lt;BR&gt;
    If not then it may be helpful to know. If you do not already take vitamin D then I would suggest that you take vitamin D 5000IU daily to reduce the atopic reaction. Discuss this with your Obstetrician. &lt;BR&gt;
    Also, as you are pregnant your child will benefit hugely from your increased D levels.&lt;BR&gt;
    You could also consider switching to MTHF (methyl tetrahydrofolic acid) or FTHF (formyl tetrahydrofolic acid, also called folinic acid) as these appear to induce histaminergic reactions less than the Folic acid. However there is no properly controlled studies on any histamine involvement from folates, only some clinical observations.&lt;BR&gt;
    The experts on this, Treasure and McKee : Herb, Nutrient and Drug Interactions have only repeated the general clinical observations/reports.&lt;BR&gt;
    You should never reduce folate rich vegetables, the consequences are too serious.
  9. mbofov

    mbofov Active Member

    Folic acid is a synthetic form of folate, and many many people have trouble converting folic acid into a form useable by the body. Below is a link to a post by the late great (seriously) Rich Van K. on the Phoenix Rising board, in which he explains why the problem with histamine stems from folic acid, and not folate. &lt;BR&gt;
    Ian is right about switching to a different form of folate. I had a folate deficiency (unrecognized for years) which has been remedied by taking metafolin and methyl B12, and avoiding folic acid.&lt;BR&gt;
    Here's the link, scroll down for Rich's post:&lt;BR&gt;
    Folic acid can actually cause a folate deficiency, as it competes for absorption with folate. It's way too bad that so many foods are &quot;fortified&quot; with folic acid.&lt;BR&gt;