For jam: Grape seed extract and osteoarthritis

Discussion in 'Fibromyalgia Main Forum' started by richvank, Jun 29, 2012.

  1. richvank

    richvank New Member

    Hi, jam.

    You're going to love this!

    PLoS One. 2012;7(5):e37728. Epub 2012 May 22.

    Procyanidin b3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model.
    Aini H, Ochi H, Iwata M, Okawa A, Koga D, Okazaki M, Sano A, Asou Y.

    Department of Plastic and Reconstructive Surgery, Tokyo Medical and Dental University, Tokyo, Japan.

    Osteoarthritis (OA) is a common disease in the elderly due to an imbalance in cartilage degradation and synthesis. Heterotopic ossification (HO) occurs when ectopic masses of endochondral bone form within the soft tissues around the joints and is triggered by inflammation of the soft tissues. Procyanidin B3 (B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity. Here, we evaluated the role of B3 isolated from grape seeds in the maintenance of chondrocytes in vitro and in vivo. We observed that B3 inhibited H(2)O(2)-induced apoptosis in primary chondrocytes, suppressed H(2)O(2)- or IL-1ß-induced nitric oxide synthase (iNOS) production, and prevented IL-1ß-induced suppression of chondrocyte differentiation marker gene expression in primary chondrocytes. Moreover, B3 treatment enhanced the early differentiation of ATDC5 cells. To examine whether B3 prevents cartilage destruction in vivo, OA was surgically induced in C57BL/6J mice followed by oral administration of B3 or vehicle control. Daily oral B3 administration protected articular cartilage from OA and prevented chondrocyte apoptosis in surgically-induced OA joints. Furthermore, B3 administration prevented heterotopic cartilage formation near the surgical region. iNOS protein expression was enhanced in the synovial tissues and the pseudocapsule around the surgical region in OA mice fed a control diet, but was reduced in mice that received B3. Together, these data indicated that in the OA model, B3 prevented OA progression and heterotopic cartilage formation, at least in a part through the suppression of iNOS. These results support the potential therapeutic benefits of B3 for treatment of human OA and heterotopic ossification.


    [Moderators: Don't worry, this is a public domain abstract from the NIH PubMed site.]

    Best regards,

  2. Mikie

    Mikie Moderator

    Also thanks for pointing out this is a public domain site.

    I was driving past a bank called, Synovius Bank. I thought to myself, "That joint must have a lot of liquid assets. Try to catch my act. I'll be here all week.

    Love, Mikie
  3. richvank

    richvank New Member

    Very cool, Mikie! Keep it up!

    Sounds like they may be a slippery operation!

  4. Mikie

    Mikie Moderator

    Thanks for the smile, Shecky :)

    Love, Mikie