The Cymbalta was killing me in terms of the migraines... Or so we suspected. I have chronic migraines anyway, but the headaches were dramatically worse: 4-5 days/week, usually waking up with them, had my first incident in ages that required more serious medical intervention, etc. I'd been on Cymbalta for about a year and it helped a ton with the feeling that i get every AM with swollen legs & feet, creakiness, feeling like i never sleep through the night, etc. Loved it... but those headaches. Anyway, my doc decided to switch me to Lyrica and almost immediately the migraines disappeared. I'm not sure yet whether it works as well as the cymbalta on the other FM symptoms, but the trade-off (the headaches) was preventing me from getting to work on time, from relaxing on a weekend, causing me to spend crazy hours catching up with work and family missed b/c of the headaches... That's greatly improved since the switch. Just thought that I'd share. Hope it's useful for someone.