I have juvenile rheumatoid arthritis in addition to FM/CFIDS. I know many people have other autoimmune issues as they tend to run in "clusters". My question is, do you find that you medications for your other conditions can greatly contribute to your FM/CFIDS? The reason I ask this is my rheumatologist recently tried to increase the methotrexate I take for my JRA, and my FM, which has been under pretty good control the last few months flared TERRIBLY, and so did my depression and brain fog. I called him and told him I could not tolerate it at that level. When I went back down on the dose, the FM pain "miraculously" died back down. Now I am wondering if the methotrexate is the actual cause of my FM/CFIDS! It is a very potent, toxic chemo drug, by the way, in case you are unfamiliar with it. Anyone else have a similar experience? If so, is there a better medication for severe inflammatory arthritis that does not cause this problem? Thank you.