I'm on my 2nd bottle of mepron. The other day I had a long day, and that night was attacked all night as though I was not being treated at all. I went thru lots of warm clothes, drenching them, and freezing most of the night. I turned the heat up, but was still shivering cold. Is this normal? Or has my bottle gotten too hot, or too cold and is no longer good? It seemed worse than before I started treatment! Of course, I have an appt. coming up, and will ask my LLMD about it. I was just really thrown by this.