Fruit Juice Can Interfere With All Medications

Discussion in 'Fibromyalgia Main Forum' started by jasminetee, Aug 21, 2008.

  1. jasminetee

    jasminetee Member

    When my husband sent me articles on this yesterday we were concentrating on the med I took that my doctors think I didn't absorb well enough which was Valcyte so I made a thread about it. I don't take other meds so I didn't think about them but actually the articles don't mention particular meds, fruit juice and possibly fruits can affect the absorption of any of them.

    "Professor Bailey said: 'Juice taken four hours prior to drug intake did not have an effect. Thus, it should be possible still to take grapefruit, orange and apple juices while on affected medications provided there is a sufficient time interval."

  2. gapsych

    gapsych New Member

    Interesting. Several years ago there was a warning on my cholesterol medication that said do not drink grapefruit juice. I am not a grapefruit fan but sure do the others.

    Good information to know as I kept wondering why the warning is not there anymore and of course my foggy mind keeps forgetting to ask the pharmacist.

    Take care.
  3. RENA0909

    RENA0909 New Member

    Here in UK it has been in the papers and on the news today telling us to take meds 4 hours before fruit juice.

    And I always take my meds 1st thing in the morning with water ........then have a BIG glass of juice called V8.It contains 8 fruits and veg and I love it.

    I will have to take my juice with lunch now just to make sure!

  4. grace54

    grace54 New Member

    I like to drink grapefruit juice. But a friend told me that grapefruit juice may interact with the medications I take. What does this mean?
    - Albert / Texas

    Mayo Clinic dietitian Katherine Zeratsky, R.D., L.D., and colleagues answer select questions from readers.

    Grapefruit juice provides many nutrients, such as vitamin C and lycopene. But chemicals in grapefruit interfere with the enzymes that break down (metabolize) certain drugs in your digestive system. This can result in excessively high levels of these drugs in your blood and an increased risk of serious side effects.

    The exact chemicals in grapefruit juice that cause this interaction aren't known. But these chemicals are present in the pulp and peel of grapefruit as well as in the juice. For this reason, any grapefruit product — including dietary supplements that contain grapefruit bioflavonoids — can interact with certain medications. If you avoid grapefruit, you may also want to avoid tangelos, a hybrid grapefruit, and Seville oranges, a type of bitter orange often used to make marmalade and compotes. They may have a similar effect.

    Grapefruit and drug interactions
    The following drugs are known to have potentially serious interactions with grapefruit products, tangelos and Seville oranges.

    Drug name Type of drug
    Carbamazepine (Carbatrol, Tegretol) An anti-seizure medication
    Buspirone (BuSpar), clomipramine (Anafranil) and sertraline (Zoloft) Antidepressants
    Diazepam (Valium), triazolam (Halcion) Tranquilizers
    Felodipine (Plendil), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular) and possibly verapamil (Isoptin, Verelan) Calcium channel blockers used to treat high blood pressure
    Saquinavir (Invirase) and indinavir (Crixivan) HIV medications

    Simvastatin (Zocor), lovastatin (Mevacor, Altoprev) and atorvastatin (Lipitor), simvastatin-ezetimibe (Vytorin) HMG-CoA reductase inhibitors used to treat high cholesterol

    Cyclosporine (Neoral, Sandimmune), tacrolimus (Prograf) and sirolimus (Rapamune) Immunosuppressant drugs
    Amiodarone (Cordarone) A drug used to treat and prevent abnormal heart rhythms (arrhythmias)
    Methadone Pain relief medication
    Sildenafil (Viagra) Erectile dysfunction medication

    If you take any of these drugs, you should completely avoid grapefruit products, tangelos and Seville oranges, unless otherwise directed by your doctor. Waiting to take these medications — even up to 24 hours — after you drink grapefruit juice will not prevent an interaction.

    Talk to your doctor or pharmacist if you have concerns about the effect of grapefruit products on any of the medications you take.

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