Hi All, I'm posting this in hopes someone may benefit from this info. I'm not a Dr of course, and am not suggesting everyone try this (but it's helping me). I was doing some research today about pain meds, drug interactions, etc and found some good info. This is a paragraph from "The Intractable Pain Patient's Handbook for Survival" by Forest Tennant, MD, DrPH (found at http://pain-topics.org/pdf/IntractablePainSurvival.pdf#search=%22dexedrine%22). I have been on a combo of meds the past 6 mos or so that have improved my quality of life. Instead of having to take Norco every 4 hours, I now take just 10mg Methadone once a day. No more peaks and valleys from the Norco wearing off...but I can still take it for breakthru pain. **Now, I know many people are against the use of stimulants, so please don't attack me** I also take 30mg Dexedrine ER daily which helps improve my energy level, my cognitive abilities, and also REDUCES MY PAIN! (I have tested this theory out by taking "holidays" from the Dexedrine) Well, now I know why...the Dex is a potentiator for Opioid pain meds, meaning it helps boost it's effectiveness and reduces pain! I was pretty sure this was the case, and there are other potentiators listed in this paragraph. Hope maybe it will help someone..... POTENTIATORS: WHAT ARE THEY AND HOW TO USE THEM The term "potentiator" is one used by physicians and pharmacists to indicate that one medical agent makes another more "potent." Here, we are talking about agents that make opioids act stronger and last longer. Potentiators allow less opioid to be used and lessen their complications. In this day and age of cost cutting, most IP (Irretractable Pain) patients will have to learn to use potentiators because insurance plans will not pay for the most effective opioids. Additionally, when you wish to decrease your opioids or attempt to withdraw, you will need to use a lot of potentiators. Common agents which potentiate opioids and which are commercially placed in some opioids are: Caffeine, Aspirin, Acetaminophen, and Ibuprofen. For example, Vicodin®, Percocet®, and Darvocet® contain acetaminophen. Fiorinal® contains caffeine and aspirin. Vicoprofen® contains ibupro- fen. Other agents including some muscle relaxants and stimulants potentiate opioids. IP patients should take a variety of potentiators to determine which ones make your opioid more effective. IP patients must especially learn to take a potentiator with their breakthrough opioids since a potentiator can help break a flare. Here is a partial list of some potentiators which may boost your breakthrough opioid: Caffeine Tablet Dexedrine Acetaminophen Phentermine Midrin® Aspirin You should systematically try potentiators one at a time to determine how best to control breakthrough pain without the benefit of expensive commercial opioid preparations such as fentanyl (Actiq® or Fen- tora®).