Gene NTE

Discussion in 'Fibromyalgia Main Forum' started by elliespad, Feb 2, 2006.

  1. elliespad

    elliespad Member

    This is just ONE Gene referenced in the much talked about article and video, "Gene Disturbances in CFS".

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    Homepage More Evidence--Pesticides Cause Brain Damage

    Genetic Link Found for Pesticides, ADHD, Gulf War Syndrome

    Environment News Service
    March 17, 2003

    LA JOLLA, California, March 17, 2003 (ENS) - Supported by a
    $1.5 million grant from the U.S. Department of Defense, research
    at the Salk Institute have identified a gene that may link certain
    pesticides and chemical weapons to a number of neurological
    disorders, including the Gulf War syndrome and attention
    deficit/hyperactivity disorder (ADHD).

    The finding, published in the March 17 online version of "Nature
    Genetics," is the first to demonstrate a clear genetic link between
    neurological disorders and exposure to organophosphate
    chemicals.

    The gene is one that scientists had not studied in previous efforts to
    find connections between these chemicals and disease.
    Organophosphates include household pesticides as well as deadly
    nerve gases like sarin.

    The Gulf War syndrome is a "loosely defined collection of
    symptoms," the researchers said, "ranging from headache and fever
    to severe forgetfulness and movement disorders." It was first noted
    after Operations Desert Storm and Desert Shield in 1991, when
    U.S., Canadian and British military veterans reported more
    symptoms than soldiers who were not deployed. Its cause is
    unknown.

    Dr. Carrolee Barlow, who led the work at the Salk Institute and is
    now at Merck and Co., Inc., and her team, headed by Christopher
    Winrow, found in mice that organophosphate exposure inhibited
    the activity of a gene called neuropathy target esterase, or NTE.
    The gene is active in parts of the brain controlling movement - the
    hippocampus, the cerebellum and the spinal cord.

    This inhibition either killed the mice before birth, or led to a range
    of behaviors very similar to ADHD. Some of the neurological
    problems were similar to symptoms seen in Gulf War syndrome.

    "This study shows that there may indeed be a genetic connection
    that explains how organophosphates can cause these reactions; it's
    just not what we assumed it would be," Barlow said.

    "There have been anecdotal links made between rises in attention
    deficit/hyperactivity disorder, Parkinson's disease and other
    disorders and exposure to pesticides," she said. "There also has
    been suspicion of a link to Gulf War syndrome. But scientists have
    been focusing on enzymes that act on acetylcholine
    neurotransmitters.

    Barlow's group had originally been looking at how environmental
    factors immediately affect the nervous system. They found that
    mice bred to lack the NTE gene died before birth.

    But the group also found that mice with only one copy of the NTE
    gene, when exposed to experimental organophosphates and
    examined over a prolonged period, exhibited behavior similar to
    attention deficit/hyperactivity disorder.

    "NTE is a large gene," said Barlow. "It's possible that we all have
    slightly different forms of the NTE enzyme, which may explain
    why some may get ADHD when they're exposed at young ages,
    and why some may get Gulf War syndrome at a later age, or why
    some of us have no symptoms at all. It appears to be a case of
    delayed toxicity, inhibiting the function of NTE."

    The Salk Institute for Biological Studies is an independent
    nonprofit organization dedicated to fundamental discoveries in the
    life sciences, the improvement of human health and conditions, and
    the training of future generations of researchers. The institute was
    founded in 1960 by polio vaccine discoverer Jonas Salk, M.D.,
    with a gift of land from the City of San Diego and the financial
    support of the March of Dimes Birth Defects Found

  2. PVLady

    PVLady New Member

    This is a very good article, thanks for posting!!
  3. PVLady

    PVLady New Member

    This is a very good article, thanks for posting!!
  4. elliespad

    elliespad Member

    Part of my ongoing RANT. But, ORGANOPHOSPHATES are just ONE class of LIFE DESTROYING PESTICIDES. There are five classes. And ten of thousands of chemicals withing each class.