Genetic factors in FM: differentially altered frequencies of immune cells

Discussion in 'Fibromyalgia Main Forum' started by tansy, Dec 1, 2008.

  1. tansy

    tansy New Member

    May genetic factors in fibromyalgia help to identify patients with
    differentially altered frequencies of immune cells?

    Clin Exp Immunol. 2008 Dec;154(3):346-52.

    Carvalho LS, Correa H, Silva GC, Campos FS, BaiĆ£o FR, Ribeiro LS,
    Faria AM, d'Avila Reis D.

    Department of Morphology, Universidade Federal de Minas Gerais, Brazil.

    PMID: 19037919

    There is common agreement that fibromyalgia (FM) is an extremely
    heterogeneous entity. Patients differ in their clinical symptoms,
    endocrine and immune parameters. In this study we evaluated endocrine
    and immunological features of distinct subsets of FM patients.

    In contrast to previous attempts to identify subsets of FM patients,
    based solely on their psychological and cognitive features, herein we
    propose to separate FM patients by genetic features. Allelic
    expression of the polymorphic promoter region of the serotonin
    transporter (5-HTTLPR) was analysed as a relevant genetic factor for

    Seventy-five patients meeting the American College of
    Rheumatology criteria and 27 healthy age-matched controls
    participated in this study. All controls and FM patients were
    submitted to genotyping of 5-HTTLPR.

    Twenty-seven FM patients, who
    were able to discontinue hypnotic, sedative or psychotropic
    prescription medications for at least 2 weeks, were then subdivided
    into L (homozygote LL) or S groups (genotypes LS and SS). They were
    evaluated for salivary cortisol levels, absolute number of leucocyte
    subpopulations, including natural killer (NK) cells and activated T
    and B lymphocytes.

    Both groups presented decreased cortisol levels, more intense in the
    L group, increased all B lymphocytes subsets and reduced
    CD4(+)CD25(high) T lymphocytes. The L group had increased
    CD4(+)CD25(low) activated T lymphocytes, while the S group displayed
    elevated CD4(+)human leucocyte antigen D-related (HLA-DR)(+)
    activated T lymphocytes and decreased NK cells.

    We demonstrate that genetic factors may help to identify FM
    individuals with differentially altered frequencies of immune cells.