Genetic / Racial Factors in FMS

Discussion in 'Fibromyalgia Main Forum' started by bakron, Aug 14, 2003.

  1. bakron

    bakron New Member

    Possible Genetic (Chromosomal) Link

    During a study of women with breast implants and symptoms and women with fibromyalgia some time back, both were significantly more likely to have an HLA molecule called DR-53. The molecule was present in 68 percent of symptomatic breast implant patients and 65 percent of fibromyalgia patients, compared with 35 percent of the asymptomatic implant patients. Fifty-two percent of the healthy women also had the DR-53 molecule, which is similar to its natural frequency among white women. DR molecules play a critical immunoregulatory role because they control the interactions among the immune system's T cells, B cells and antigen-presenting cells. (Study from 4-18-96 / Caroline Decker)

    The above study did not prove that breast implants cause FMS, but that those who had problems with the breast implants were more likely to have the DR-53.

    HLA-DR53 has its own peptide-binding motif. The most abundant peptide eluted from the DR53 molecule comes from an intracellular protein, calreticulin (CRT), which is involved in MHC class I biosynthesis, heat shock response and tumor rejection. Two of the functions of calreticulin are:

    1. Calreticulin may be involved in the signaling pathway for the induction of Ca(2+)-dependent processes and may represent one regulatory mechanism operating in activation of T-lymphocytes. Cytotoxic T lymphocytes (CTL) recognize surface markers on other cells in the body that label those cells for destruction. In this way, CTLs help to keep virus-infected or malignant cells in check.

    2. Calreticulin also functions as a molecular chaperone in the biosynthesis of myeloperoxidase. Myeloperoxidase (MPO) a lysosomal enzyme is critical to the oxygen-dependent killing of bacteria by phagocytic leukocytes. This is an absolutely critical oxygen-dependent killing system, without which leukocytes have great difficulty killing bacteria.

    The above requires further study to ascertain correlation with FMS, or as a possible cause of FMS. If a cause of FMS, the cause is most likely due to a physical stressor on the body that creates a production of calreticulin and resultant possible autoimmune type response. NOTE: Since DR-53 is chromosomal linked; it may also indicate a genetic predisposition. <b>It would be interesting to see a racial breakdown as to prevalence of the DR-53.</b>