Glutathione depletion in AUTISM and the spinoff for CFS

Discussion in 'Fibromyalgia Main Forum' started by wish_to_be_healthy, Jan 15, 2007.

  1. wish_to_be_healthy

    wish_to_be_healthy New Member

    From Co-Cure ME/CFS & FM info Exchange Forum:

    Hypothesis:


    Posted by Rich Van Konynenburg Sat, 16 Apr 2005 01:32:45 -0400


    Glutathione depletion in autism and the spin-off for CFS
    As regular readers on this list will know, I have been emphasizing the importance of glutathione depletion in the pathogenesis of CFS for several years now, since Dr. Paul Cheney first reported it in public talks early in 1999.
    I want to notify everyone here about some developments that I think are significant in this regard.

    About two weeks ago, on April 2, Dr. S. Jill James of the University of Arkansas gave a talk at the Experimental Biology 2005 conference in San Diego on the research she and he coworkers have done on autism. They have found that in kids with autism, the reduced form of glutathione is depleted by about 80%. This was reported in a paper they published earlier. In addition, they reported that they have now looked for single nucleotide polymorphisms (SNPs) in genes that may account for this glutathione depletion. They found that in kids with autism, SNPs were elevated in the genes coding for the enzymes catechol-O-methyltransferase (COMT), glutathione-S-transferase M1, and transcobalamin II.

    Dr. James suggested that autism occurs when there is a combination of a certain genetic makeup and an environmental insult that interacts with it. In autism, this environmental insult may be mercury, as from the thimerosol in vaccines, which many autism parents have suspected to be involved in causing autism in their children. As most readers will know, the body uses glutathione to rid itself of mercury. In children who are less able to maintain their glutathione levels for genetic reasons, mercury may be more toxic.

    I think that this is very exciting. I think that there could very well turn out to be many parallels between autism and CFS. The difference may be that autism occurs when glutathione depletion occurs early in life, while CFS occurs later in life, after the brain has had a chance to develop.

    I think that CFS research will benefit from these developments in autism. This talk got wide news coverage around the world. The autism parents are highly motivated, and many have resources. They are politically organized and capable of exerting considerable clout. I expect an increase to occur in research into glutathione depletion and into testing for relevant SNPs. I think this can only help CFS research, since I believe that glutathione depletion is very important in CFS as well.

    All this is happening at the same time that a breakthrough has occurred in cystic fibrosis research that also involves glutathione (by Valerie Hudson at BYU in Utah). In cystic fibrosis, it appears that cells have difficulty in exporting glutathione. There is another highly motivated set of parents associated with this disease, and I expect that they will also be promoting research into glutathione.

    We all know how difficult it has been to get scientific interest and funding for research into CFS. I think we are now about to benefit from spin-offs from research into these other diseases. I think that this is a very interesting turn of events.

    Rich Van Konynenburg, Ph.D.


  2. Mikie

    Mikie Moderator

    To increase glutathione is with the undenatured whey sold here. ImmunePro is Dr. Cheney's favorite. I take the ImmunPlex and feel it has helped me. My ex has been feeling very tired. He's now on ImmunPlex, colostrum, and a good probiotic. He's already feeling better.

    Love, Mikie
  3. elliespad

    elliespad Member

    I ABSOLUTELY believe that a GENETIC Predisposition to faulty/decreased Glutathione production followed by a MAJOR chemical/toxic assault is to blame, For Autism, or our DD. NO DOUBT in my mind.
    [This Message was Edited on 01/16/2007]
  4. wish_to_be_healthy

    wish_to_be_healthy New Member

    Yes...Whe I read this last night, I was thinking it is time to look into taking it...and my boys too.

    Thanks for the tip on the whey, I was looking at their supps last night..trying to figure out which would be best.

    Suz
    [This Message was Edited on 01/16/2007]
  5. Mikie

    Mikie Moderator

    That genetics play a large role in our illnesses. There have already been mutated genes found in PWC. Other factors include stress, infections, and trauma.

    These illnesses provide such a wide range of symptoms that, until there is a cure, we have to fight the illnesses on as many fronts as necessary to achieve healing.

    Once one does start to heal, even with setbacks, the various treatment start to work together to produce better results than one would get from each treatment itself.

    It is soooooo much work to try to achieve healing but my belief is that if we do nothing, we will get sicker.

    Love, Mikie
  6. wish_to_be_healthy

    wish_to_be_healthy New Member

    my rheumy is tires of dealing with my case...It would be easier for him to keep me on 2 Vicodin a day, no more...and he was surprised when I told him, I rolled of of it anyway...why go back on it, after all that trouble?

    I seem to be having trouble with Mirapex...I am so sensitive...I need to start slow, and work up.

    I vacilate between western and alternative medicine...after 20 years, and a 9 month flare (my longest ever) I have to go in a new assertive direction...He's not keen on it...

    I'm finding a new doc,

    Suz
  7. Mikie

    Mikie Moderator

    I use a combo of traditional medicine and alternative treatments. I think we each have to find what works for us. We do need good docs who are interested and proactive. Good luck.

    Love, Mikie