Growth Hormone Deficiency OR FMS!!!

Discussion in 'Fibromyalgia Main Forum' started by darude, Aug 4, 2005.

  1. darude

    darude New Member

    Human Growth Hormone Deficiency
    GHD can affect your life quality
    If you are diagnosed with GHD because of low or absent growth hormone (GH) secretion levels you may
    experience a number of different physical and emotional symptoms. Feeling tired, listless, easily fatigued,
    and having a lack of motivation are often reported by patients. Some individuals also report feeling anxious,
    irritable, losing interest in sex, and a pervasive sense of gloom and pessimism about their lives. Because
    of these effects, persons with GHD may tend to avoid contact with others, show signs of stress in their
    marriage, and experience a gradual decrease in their productivity at work. Quality of life begins to decline
    and the affected individual often suffers in silence.
    Although we refer to it as "growth" hormone, GH actually has many other functions than helping growth to
    occur. GH is a powerful brain hormone that is believed to play an important role in stimulating and controlling
    areas of the brain that regulate moods and emotions. Certain chemicals in the brain, called neurotransmitters
    are dependent on the effects of GH to help them carry their messages between brain centers. If GH is not
    available, these functions may not occur appropriately and the result can be uncontrolled changes in
    psychological functioning. Individuals may feel anxious, depressed or worried for no apparent reason when
    this happens, and this may cause changes in behavior or decline in social functioning. Negative and sad feeling
    may dominate your mood, and positive or joyful feelings can be dampened. An affected individual could feel
    unable to enjoy life and lack the motivation to make change in their circumstance. It is important to remember
    that these emotional changes are not usually directly related to actual life events and therefore are difficult to anticipate.

    Human Growth Hormone Deficiency and the Immune System
    Growth Hormone increases the orchestrators of endogenous stem cell migration, differentiation and integration to effect
    tissue healing, especially the liver, immune system, adrenal gland, and the hypothalamus.

    TH1 (T Helper 1) goes after living organisms that get inside our cells = cell mediated immunity. TH2 (T Helper 2) attacks
    extra cellular pathogens, living organisms found outside the cells in blood and other body fluids = humoral or antibody
    mediated immunity. The healthy immune system can switch back and forth eradicating the threat and then rest. When
    the resting cell is exposed to a virus, cancer, yeast or intracellular bacterial (Mycoplasma, Chlamydia pneumonia) an
    immune response is initiated. The weapons of TH1 system, include cytoxic T cells and natural killer cells (NK).

    Bacterial toxins producing allergies trigger the other side, TH2. Its weapons include esoinophils, neutrophils and
    antibody secreting cells. The main stem cell has to make a choice: Interluekin 12 (IL-12) goes to TH1 and Interluekin
    10 (IL-10) goes to TH2. Viruses like EBV, CMV and HHV-6, make protein that mimics IL10. The virus deceives
    the immune system into shifting to the TH2 system.

    Researchers show that most CFIDS end up stuck in TH2 mode. The consequences: when TH2 is activated it
    ocks the TH1 system, especially the NK cell function and the TH2 increases white cells, especially antibody production.

    As an example, everything the CFIDS patient has been exposed to will show elevated TH2 system, thus over
    responding to toxins, allergens, normal bacteria, yeast, cancer, and intracellular bacteria. When the body is
    TH2 dominant the body can no longer have the defenses to suppress and keep dormant those things caught long
    ago, ie, cannot control EBV, Chlamydia pneumonia, HHV-6, etc; these infections become reactivated as does yeast.
    There is no activation of TH1, thus no front line immune system protection.

    Growth Hormone Deficiency and the Chronically Ill

    Growth Hormone Deficiency (GHD) (Table 3) occurs in patients with pituitary tumors, trauma, and
    post-surgically, comprising approximately 50% of the total etiology of GHD. I submit that the remaining
    50% is associated with chronic inflammatory diseases, characterized by immune system dysregulation,
    adrenal dysregulation and hypercoagulation state.

    The GHD symptom complex can occur after a chronic illness and has been studied extensively in
    relation to CFS, FMS, rheumatoid arthritis, and other diseases. The concept of anoxia caused by the
    immune system activation of coagulation with infection cytokine excess and vasculitis contributes
    to the decline and dysregulation of HPA axis.

    Clinical Endocrinology (2000) 53 pp 99 – 10

    Characterization of pituitary function with emphasis on GH secretion in the Chronic Fatigue Syndrome. Greta Moor Kens

    Impaired GH response in insulin induced hypoglycemia
    Low nocturnal GH secretion, no changes note in IGF-1 levels
    Prolactin and TSH levels elevated
    CFS hypothesis is a decreased dopaenergic tone in CFS
    Disturb hypothalamus – pituitary, adrenal, axis is impaired
    Is a stress related illness
    Glucocorticoid metabolism is impaired
    Study eleminate acute illness in past 6 months, pregnancy, chronic liver disease, thyroid dysfunction, hypertension, diabetes, malignancy, chronic medication had last 18 months no post viral onset.
    Impairement of dopaminergic neurotransmission may underline the indocrine disturbances of CFS
    GH deficiency patients have higher PAI, plasma activitor inhibitor and increase fibroginen
    GH deficiency doesn’t seem to effect blood pressure
    Comparison of Fibromyalgia (FMS) Symptoms and Growth Hormone Deficiency

    Fibromyalgia (FMS) Growth Hormone Deficiency (GH Deficiency)
    Muscle weakness Muscle weakness
    Fatigue-low energy Fatigue
    Decrease exercise capability Decrease exercise capability
    Social isolation Social isolation
    Poor general health Poor general health
    Cold intolerance Cold intolerance
    Impaired cognition Impaired cognition
    Dysthymic Dysthymic
    Decrease of body mass Decrease of body mass
    IGF-1 reduced IGF-1 reduced
    Decrease 24 hr. GH secretion Decrease 24 hr. GH secretion
    Respond to GH treatment Respond to GH treatment

    GHD in adults is associated with:
    Premature atherosclerosis
    Disturbed lipoprotein pattern – elevated lipid (cholesterol LDL, triglycerides
    Excess weight and central adiposity
    Impaired glucose homeostatis – symptoms of low blood sugar
    Impaired fibrinolysis
    Impaired cardiac functioning – weakened heart muscle contraction
    Decrease exercise capacity – due to decrease cardiac output
    Reduction in arterial distensibility and stiffness especially in the carotid in women
    Increased tone in the sympathetic nervous system. Major risk factor in CHF and heart disease and premature death
    Nitric oxide levels are low contributes to atherosclerosis
    Have significant more health issues, more sick days and on disability
    Decrease bone mineral content
    Decrease activity in osteoclast precursor and proliferation and differentation of asteoclasts (effects on osteo blasts also mediated through IGF-1, risk for fractures)
    Abnormal body composition
    -Increase abnormal obesity
    -Decrease muscle strength and size
    -Decrease lean body mass
    - Decrease ostoporosis and fractures
    Problem with sleep quality
  2. elsa

    elsa New Member

    My husband and I are leaning more and more in the direction of HGH deficiency and my symptoms. I think strongly that my FM/CFS is the "egg" and HGH Def. is the "chicken". It just makes too much sense that GH needs to be addressed along with the other hormones.

    I really appreciate all the information you are posting lately concerning hormones. I think I am very close to seeing a specialist concerning this HGH issue.

    Thanks again for the effort in keeping us informed.

  3. darude

    darude New Member

    Because I have a pituitary tumour and that can cause all of this. I'm invesigating it all now and feel this COULD be the cause of my problems. Slowly but surely the pieces of the puzzle are coming together.
  4. TXFMmom

    TXFMmom New Member

    Many things studied by Dr. Bennet in Oregon have found low HGH levels in FM patients.

    I tested extremely low several years ago and continue to do so, but I had a melanoma a number of years ago and Harvard would not include me in their program which treats adults with HGH deficiency because it could stimuloate regrowth or metastasis.

    For thosw without that problem it can be a useful treatment.

    It is, however, quite expensive, or it was at $1,000 per month.
  5. wangotango

    wangotango New Member

    seeing the post you pur up just reminded me of something that i had forgotten about and is also a landmark for me as well.
    in 1998 when i was 1st starting to have a little bit of weird symtoms, which i chalked up to working 12hr shifts in the er and going to school from 8 am to 3 pm the next day one of the docs i worked with suggested HGH supp in a nasal mist. i got it and started to use it as directed and after about 8 months had to stop due to what i thought might be side effects.
    i am going to refresh my mind on what actions the HGH takes when it is used. maybe in my case the HGH exacerberated my pituitary tumor's growth. any way good info
  6. rt6176

    rt6176 New Member

    I use to take Dr Orman's HGH Plus to give me that energy boost that people here so dearly need. It was a lifesaver.

    It is an all natural suppliment mixture to stimulate the pituitary gland.

    At the beginning of last year, Dr Orman changed the way it was formulated to remove its lumpy gritty texture.

    Not only did the new formula not give me any energy, it made me ill.

    I begged and pleaded for the old formula, "Sorry" was the response.

    I am so tired today.

  7. darude

    darude New Member

    Since coming down with all this garbage I love my research!!!!!!!!!!!!!!!! Can't get enough info. My theory is we all having underlying causes and we have to find out what they are. The docs appointments are a pain but one day might hit the nail on the head.

    ANNXYZ New Member

    helps insure normal HGH levels . I had good results
    with trazadone and low dose naltrexone . Both have kept my HGH level NORMAL .
  9. foxglove9922

    foxglove9922 New Member

    darude, timely post for me. I gave up on Humatrope a month ago because my IGF-1 slipped to 57. The doc added in Salsalate with the same HGH injection dose and WALLA, I'm up to 128 and definitely feeling better....foxglove

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