I was doing some research and came across this info regarding Guaifenesin. I have always suspected that there is more to the story than Dr. St. Amand's theory regarding how the Guai reverses FMS symptoms. If our immunity is strengthened, we will feel better and the Guai may play a role in healthier immunity. I found this in the Journal of Immunity. Love, Mikie ****************************** Guaifenesin, an expectorant, may enhance mucosal immunity by increasing mucosal IgA levels. Guaifenesin claim to fame is as an expectorant that loosens and thins mucus. That might suffice to help explain how guaifenesin helps overcome a sinus or respiratory infection as a treatment, but this alone does not adequately explain how quaifenesin can prevent strep and other infections of the sinus and lungs when taken as a preventative. What I have found lacking in the published literature are studies of the effects of guaifenesin on cytokines like IgA, IL-12, antigen presentation, DTH and other immune markers. RH Buckley writes that "Selective absence of serum and secretory IgA is probably the most common form of human innumodeficiency. High frequencies of recurrent sinusitis, otitis media, pneumonia and atopy were noted among a group of 75 such patients all but 4 of whom were Caucasian." (1) Numerous studies have linked IgA deficiency with sinusitis, bronchitis, allergies, rheumatoid arthritis, sore and swollen joints, anemia, low platelet count, food allergy and asthma. (2, 3) Lizeng Q et all found that serum IgA suppressed the replication of HIV-2. Lizeng found 96% of all IgA samples reacted against whole HIV-2 antigen and 100% reacted with gp 36. (4) Challacombe and Sweet state: "There is a paradox that profound HIV-induced immunodeficiency is present systemically, whereas the majority of infections associated with HIV disease are present or initiated at mucosal surfacesä. Considerable attention has been given to the possibility of mucosal immunization against HIV and there is evidence that secretory IgA antibody is neutralizing to different HIV strains." (5) 1. Clinical and immunologic features of selective IgA deficiency, RH Buckley, birth Defects Orig Artic Ser. 1975;11(1):134-42 2. http://www.primaryimmune.org/pubs/ 3. Immunologic defects in patients with chronic recurrent sinusitis, Sethi DS et al, Otolaryngol Head Neck surg. 1995 Feb;112(2):242-7 4. IgA mediated immunity in HIV-2 infection, Virology, 2003 apr 10;308(2):225-32 5. Oral Dis. 2002;8 Suppl 2:55-62 Medical Hypothesis: Guaifenesin, with other factors (Vitamin A, silica, the probiotic B-longum etc) promote mucosal immunity and could inhibit HIV progression As guaifenesin reverses many of the conditions associated with chronic IgA deficiency, studies are need to determine if, in fact, guaifenesin actually increases mucosal IgA levels. At this juncture, there does not appear to be any other logical theory as to why guaifenesin would have these protective effects on the mucus membranes other than improving the status of mucosal IgA. Vitamin A is also grossly under used in the battle against AIDS, candidiasis and CFIDS. A and D from fish oil in capsules of 10,000 i.u of A and 400 i.u of D should be taken daily. Initially, 2 capsules twice daily for the first month then reduce to 2 capsules daily.