Gulf War Veterans FM like symptoms treated with AntiBiotics

Discussion in 'Fibromyalgia Main Forum' started by AJME, Nov 22, 2002.

  1. AJME

    AJME New Member

    Does anyone know if the results of a 1 year test for Gulf War Syndrome (FM like) treatment with Doxycycline has been published. Below is Abstract of summary

    ************************

    Treatment
    Project Summary


    Title: Antibiotic Treatment of Gulf War Veterans' Illnesses (ABT) (See also DoD-119)
    Synopsis: This study's objective tries to determine whether a 12-month course of doxycycline treatment in deployed mycoplasma-positive Gulf War veterans can GWI improves patients' functional status
    Overall Project Objective: See also DoD-119. Determine whether a 12 month course of doxycycline treatment in deployed mycoplasma positive Gulf War veterans with Gulf War Illness improves patients' functional status compared to placebo.
    Status/Results to Date: This study has been recently completed. 491 patients (109% of the expected goal) from 28 sites, including two DoD sites, were randomized into the study. This provides 95% power for the determination of whether a significant difference exists between the two treatment groups at the primary endpoint. The results of the study have been analyzed and were presented to the Data Monitoring Board in December, 2001. In addition, the results have been submitted for publication in a scientific journal. It is expected that the study will be published in the spring/summer of 2002.
    Project: VA-55
    Agency: Department Of Veterans' Affairs
    Location: VAMC Perrypoint/Multiple Sites

    P.I. Name: Sam T. Donta, M.D.
    Research Type: Clinical
    Research Focus: Treatment
    Focus Category: Treatment
    Status: Ongoing
    Study Start Date: March 01,1999
    Estimated Completion Date: December 31,2001
    Specific Aims: Determine: 1) whether doxycycline treatment reduces symptoms of GWI, 2) whether doxycycline treatment converts Mycoplasma (+) patients to mycoplasma (-) status, and 3) if the benefits of 12 months doxycycline treatment endure after termination of treatment.
    Methodology: This study was a 30 month, prospective, randomized, double-blind clinical trial. Patients were randomized to one of two treatment groups: 1) patients treated with doxycycline for 12 months and, 2) patients given placebo for 12 months. Each patient received study medication for 12 months and were followed for an additional six months after the termination of medications. Patients were seen monthly during the medication phase and at 18 months. Major evaluations were completed at baseline and at 3, 6, 9, 12, and 18 months. 450 GWI patients from 30 medical centers were planned to be entered into the study over a one-year recruitment period. All veterans deployed to the Gulf War between August 1990 and August 1991 were eligible. Patients were considered to had GWI if they have at least two of three symptoms (fatigue, musculoskeletal pain, neurocognitive dysfunction) that began after August 1990 and that have lasted more than six months and up to the present. Patients who tested positive for Mycoplasma fermentors, Mycoplasma genitalium, and/or Mycoplasma pneumoniae at baseline were eligible to enroll. Patients assigned doxycycline received 200 mg/day. All patients were provided with a potent sunblock preparation for protection from common drug-related photosensitivity.
    Most Recent Publications:
    Donta ST, Engel CC, Baseman JB, Collins JF, Martin SK, Feussner JR. Doxycycline Therapy of Mycoplasma-Positive Veterans with Gulf War Illness. Conference on Illnesses among Gulf War Veterans" A Decade of Scientific Research, January 24-26, 2001. Presentation

    Collins JF, Donta ST, Engel CC, Baseman JB, Dever LL, Taylor T, Boardman KD, Martin SK, Wiseman AL, Feussner JR. The Antibiotic Treatment Trial of Gulf War Veterans Illnesses: issues, design, screening, and baseline characteristics. Control Clin Trials, 23(3):333-53, Jun 2002. Abstract

  2. AJME

    AJME New Member

    Does anyone know if the results of a 1 year test for Gulf War Syndrome (FM like) treatment with Doxycycline has been published. Below is Abstract of summary

    ************************

    Treatment
    Project Summary


    Title: Antibiotic Treatment of Gulf War Veterans' Illnesses (ABT) (See also DoD-119)
    Synopsis: This study's objective tries to determine whether a 12-month course of doxycycline treatment in deployed mycoplasma-positive Gulf War veterans can GWI improves patients' functional status
    Overall Project Objective: See also DoD-119. Determine whether a 12 month course of doxycycline treatment in deployed mycoplasma positive Gulf War veterans with Gulf War Illness improves patients' functional status compared to placebo.
    Status/Results to Date: This study has been recently completed. 491 patients (109% of the expected goal) from 28 sites, including two DoD sites, were randomized into the study. This provides 95% power for the determination of whether a significant difference exists between the two treatment groups at the primary endpoint. The results of the study have been analyzed and were presented to the Data Monitoring Board in December, 2001. In addition, the results have been submitted for publication in a scientific journal. It is expected that the study will be published in the spring/summer of 2002.
    Project: VA-55
    Agency: Department Of Veterans' Affairs
    Location: VAMC Perrypoint/Multiple Sites

    P.I. Name: Sam T. Donta, M.D.
    Research Type: Clinical
    Research Focus: Treatment
    Focus Category: Treatment
    Status: Ongoing
    Study Start Date: March 01,1999
    Estimated Completion Date: December 31,2001
    Specific Aims: Determine: 1) whether doxycycline treatment reduces symptoms of GWI, 2) whether doxycycline treatment converts Mycoplasma (+) patients to mycoplasma (-) status, and 3) if the benefits of 12 months doxycycline treatment endure after termination of treatment.
    Methodology: This study was a 30 month, prospective, randomized, double-blind clinical trial. Patients were randomized to one of two treatment groups: 1) patients treated with doxycycline for 12 months and, 2) patients given placebo for 12 months. Each patient received study medication for 12 months and were followed for an additional six months after the termination of medications. Patients were seen monthly during the medication phase and at 18 months. Major evaluations were completed at baseline and at 3, 6, 9, 12, and 18 months. 450 GWI patients from 30 medical centers were planned to be entered into the study over a one-year recruitment period. All veterans deployed to the Gulf War between August 1990 and August 1991 were eligible. Patients were considered to had GWI if they have at least two of three symptoms (fatigue, musculoskeletal pain, neurocognitive dysfunction) that began after August 1990 and that have lasted more than six months and up to the present. Patients who tested positive for Mycoplasma fermentors, Mycoplasma genitalium, and/or Mycoplasma pneumoniae at baseline were eligible to enroll. Patients assigned doxycycline received 200 mg/day. All patients were provided with a potent sunblock preparation for protection from common drug-related photosensitivity.
    Most Recent Publications:
    Donta ST, Engel CC, Baseman JB, Collins JF, Martin SK, Feussner JR. Doxycycline Therapy of Mycoplasma-Positive Veterans with Gulf War Illness. Conference on Illnesses among Gulf War Veterans" A Decade of Scientific Research, January 24-26, 2001. Presentation

    Collins JF, Donta ST, Engel CC, Baseman JB, Dever LL, Taylor T, Boardman KD, Martin SK, Wiseman AL, Feussner JR. The Antibiotic Treatment Trial of Gulf War Veterans Illnesses: issues, design, screening, and baseline characteristics. Control Clin Trials, 23(3):333-53, Jun 2002. Abstract

  3. Mikie

    Mikie Moderator

    It can take longer than 12 months on the antibiotics if one has been sick a long time. Please let us know if you see the report. Thanks for posting this.

    Love, Mikie
  4. AJME

    AJME New Member

    Dear Mikie,

    I read that Doctor Nicholson did a study (found on the internet) comparing CFIDS diagnosed patients (based on current literature (non-gulf war) with 650 GWI (Gulf War Illness) patients and its AMAZING how closely 32 symptoms (percentage of symptoms) GWS vs. CFIDS were related. From Aching Joints to Eye pain. The 2 symptoms that didn't have a real close correlation was Blurred Vision and Light Sensitivity. (more common CFIDS)

    Excerpts from Report: (below that is selected case abstracts)

    "Previously, Lo et al. (17) found that doxycycline was effective in the treatment of mycoplasmal infections of the same specie. Of the 73 Desert Storm veterans who had most of the GWI-CFIDS symptoms listed in Fig. 2, 55 had good responses with doxycycline, and after multiple courses of antibiotic eventually recovered (14)."

    Below indication based on comparison between CFIDS and GWI (Gulf War Illness)symptoms.

    "This indicates that GWI is not a separate syndrome; it is a Chronic Fatigue Syndrome- or CFIDS-like disorder (ref. 7, Fig. 2). The signs and symptoms of GWI also overlap with Fibromyalgia, a condition similar to CFIDS but one that has as its major signs/symptoms muscle and joint pain."

    Table 1. Brief comments on selected GWI patients (nonscientific sample).
    ------------------------------------------------------------

    Subject A.

    36 year-old USAF MAJ, Military Intelligence, JSO, 5th Special Forces

    Deployed at King Kahlad Military City during SCUD attacks

    Within 6 m after return to US presenting with chronic fatigue, skin rashes, diarrhea, headaches, aching

    joints, muscle pain, fevers, sleep problems, vision problems, nausea, memory loss, stomach pain

    Tested Positive for M. fermentans incognitus by Gene Tracking

    Rx: Doxycycline (6 wk @ 200 then 100 mg/d) for 2 cycles

    Recovered after 3 cycles of doxycycline, relapses occasionally, especially after flying

    Subject B.

    37 year-old USN LT CMDR, SEAL Units, JSO, 5th Special Forces

    Deployed in covert JSO deep in Iraq

    Within 9 m after return to US presented with chronic fatigue, skin rashes, diarrhea, headaches, aching

    joints, muscle pain, fevers, sleep problems, nausea, severe vision problems, vomiting, lost 45 lbs.

    Illness worse after flying, diving, extreme activity

    Tested Positive for M. fermentans incognitus by Gene Tracking

    Rx: Doxycycline (6 wk @ 200 then 100 mg/d)

    After several cycles of doxycycline, completely recovered, has been promoted to USN CAPT

    Subjects C, D, E and F.

    48 year-old USMC COL, Central Command Staff, Operation Desert Storm

    Deployed in Saudi Arabia at ODS Central Command HQ

    Within 10 m after return to US presented with chronic fatigue, skin rashes, diarrhea, headaches, aching

    joints, muscle pain, fevers, sleep problems, nausea, vision problems, memory loss, dental problems

    Within 28 m wife became ill with similar symptoms; after wife became ill their two children slowly became

    sick with similar signs and symptoms

    Adults tested Positive for M. species by PCR

    Rx: Doxycycline (6 wk @ 200 then 100 mg/d); same for wife; children given azithromycin based on

    weight, then low-dose doxycycline.

    After three cycles of doxycycline, completely recovered; wife recovering, still relapses; children recovering.


    Subjects G, H and I.

    36 year-old USA CAPT (Artillery) 101st ABN DIV

    Deployed in Iraq near Base Cobra

    Within 16 m after return to US presenting with chronic fatigue, skin rashes, diarrhea, headaches, hearing

    problems, aching joints, muscle pain, fevers, sleep problems, vision problems, nausea, memory loss

    Wife became sick with similar symptoms, extreme uterine swelling; 7 year-old child with symptoms, failed

    to gain weight

    Tested Positive (entire family) for M. species by PCR

    Rx: Doxycycline (6 wk @ 200 mg/d; child, 6 wk @ 50 mg/d)

    After 8 cycles of doxycycline, about 90% recovered; wife recovering; child has recovered after 4 cycles

    Subject J.

    29 year-old female USA Specialist, Graves Registration Unit, 24th INF DIV

    Deployed at various locations in Iraq, Kuwait

    Within 12 m after return to US presented with chronic fatigue, skin rashes, diarrhea, headaches, memory

    loss, fevers, coughing, heart pain, hair loss, vertigo, dental problems, heart pain, menstrual problems,

    aching joints, muscle pain, fevers, sleep problems, nausea severe vision problems, bleeding gums

    Within 24 m partially paralyzed, requires wheelchair, O2

    Tested Positive for M. fermentans incognitus by Gene Tracking

    Rx: Cipro (4 wk @ 500 mg/d); tried doxycycline, but MCS prevented continuing on this antibiotic

    After two cycles of Cipro, improving, but not yet recovered, still requires wheelchair

    Subjects K and L.

    53 year-old USA COL (Retired, Special Forces), Press Corps

    At various locations in Saudi, Kuwait (inspected SCUD impact sites)

    Within 24 m after return to US presented with chronic fatigue, skin rashes, diarrhea, headaches, aching

    joints, muscle pain, fevers, sleep problems, nausea, vision problems, dental problems

    Significant Other presenting with chronic fatigue, severe aching joints, muscle pain, fevers, sleep

    problems, vomiting, headaches, muscle pain, menstrual problems, bloating, memory loss

    Tested Positive (both) for M. species by PCR

    Rx: doxycycline (6 wk @ 200 mg/d)

    After three cycles doxycycline, recovered, but still relapses occasionally; Significant Other recovering slowly

    Subjects M and N.

    35 year-old USA SSG (Military Intelligence), 101st ABN DIV

    At various locations in Saudi, Kuwait (inspected SCUD impact sites)

    Within 6 m after return to US presented with chronic fatigue, skin rashes, diarrhea, headaches, aching

    joints, muscle pain, fevers, sleep problems, nausea, vision problems, MCS, heart pain, coughing, hair

    loss, vertigo, memory loss, dental problems

    Spouse presenting with similar symptoms within 24 m after return of husband

    Tested Positive for M. genitalium by Gene Tracking; spouse did not take test

    Rx: doxycycline (6 wk @ 200 then 100 mg/d)

    After 1 cycle of doxycycline, stopped because of MCS, has not recovered; spouse recovering on Dox.

    Subjects O and P.

    43 year-old USA SGT (Fire Control), 101st ABN DIV

    At various locations in Iraq, Kuwait (under SCUD attack)

    Within 6 m after return to US presented with chronic fatigue, skin rashes, diarrhea, headaches, aching

    joints, muscle pain, fevers, sleep problems, nausea, vision problems, MCS, vomiting, chest pain, hair loss

    Retired, partially paralyzed, wheel chair necessary for mobility

    Wife slowly came down with similar signs and symptoms, also wheel chair bound

    Tested Positive for M. species by PCR

    Rx: doxycycline (6 wk @ 200 then 100 mg/d)

    After two cycles of doxycycline, lost paralysis, can walk without support, recovering quickly, wife is also

    recovering on doxycycline.

    Subject Q.

    30 year-old female USA LT (NBC Unit), 101st ABN DIV

    At various locations in Iraq, suspected NBC attacks, SCUD attacks

    Within 6 m after return to US presented with chronic fatigue, skin rashes, diarrhea, headaches, aching

    joints, muscle pain, loss of mobility, fevers, sleep problems, nausea, vision problems, MCS, menstrual

    problems, vomiting

    Required constant sleep, left Army

    Tested Positive for M. species by PCR

    Rx: doxycycline (6 wk @ 200 mg/d)

    After three cycles of doxycycline, recovering, working in law enforcement


    Subjects R, S, T, U and V.

    43 year-old USAF SGT (Cargo Specialist), Assigned to Dover AFB

    At Dover AFB unloaded SCUD parts, Iraqi vehicles from Air Force planes

    Within 12 m after end of ODS presented with chronic fatigue, skin rashes, diarrhea, headaches, aching

    joints, muscle pain, fevers, sleep problems, nausea, vision problems, vomiting, chest pain, hair loss

    Wife and three children showing same symptoms

    Tested Positive for M. species by PCR (every member of family was positive, except one)

    Rx: doxycycline (6 wk @ 200 then 100 mg/d)

    After 3 cycles of doxycycline, entire family recovering


  5. Mikie

    Mikie Moderator

    I appreciate the info.

    Love, Mikie