Gut panel came back (any MD here? ;)

Discussion in 'Fibromyalgia Main Forum' started by SpiroSpero, Jul 22, 2008.

  1. SpiroSpero

    SpiroSpero New Member

    Hi all,

    just received the gut panel results from Diagnos Techs.

    Totale intestinal SIgA was below 18 with nor being 400-880
    Alpha Anti-chymotrypsin 122 norm below 60
    Gliadin Ab, SIga negative
    Chymotrypsin 9 while norm is above 9
    Occult blood: positive *argh*

    pathogens: Enterococcus species: Moderate
    Citrobacter species: Moderate
    non pathogenig E. coli - moderate

    Can anyone interprete the results especially the intestinal SIgA?
  2. SpiroSpero

    SpiroSpero New Member

  3. findmind

    findmind New Member


    Any drs here? Lab techs? Pathologists?

  4. SpiroSpero

    SpiroSpero New Member

    well here's a great article:

    "Secretory IgA is an excellent biomarker of immunological status in the gastrointestinal tract and should be elevated as a healthy response to significant dysbiosis."

    The levels of sIgA in fecal specimens can be measured to assess humoral immunological activity in the gastrointestinal tract. Secretory IgA production is increased in the presence of potentially harmful antigens such as pathogenic bacteria, parasites, yeast, viruses, abnormal cell antigens, and allergenic proteins. (14) However, sIgA production may be suppressed in cases of mental or physical stress, or inadequate nutrition. Dietary restrictions, excessive alcohol intake, body mass loss, negative mood, and anxiety have been associated with lowered sIgA production. (16)

    Elevated fecal sIgA is an appropriate response to an antigenic presence. Microbial and microscopic studies of the stool are useful in identifying if bacteria, yeast, or parasites are present. SIgA should renormalize with eradication of the pathogenic microorganisms.

    Depressed fecal sIgA has been treated by probiotic supplementation of Saccharomyces boulardii, a nonpathogenic yeast. (17) Significantly elevated levels of intestinal sIgA and subsequent enhanced host immune response have been found following S. boulardii administration in mice and rats. (18,19) Depressed fecal sIgA due to inadequate diet may respond especially well to an increase of dietary L-glutamine, as the synthesis and expression of sIgA requires adequate intake of this amino acid. (16) Animal studies have demonstrated that a glutamine-restricted diet can result in a 50% decrease in intestinal sIgA levels. (20)

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