I have been suffering with this horrible condition forever and I've done a ton of research on the subject. All the cutting edge research points to two main ideas in reaching a cure, in my opinion: 1) Substance P, a cerebrospinal fluid, is much higher in FM patients, and it sends an excess of pain signals to the brain, magnifying our pain to extreme levels. Has anyone had this tested by a doctor, or in a clinical trial? If so, did insurance pay? It seems like researchers keep verifying it in tests as the villain, but there is nothing being done to find a way to fix the levels (a cure). Also, does anyone know if there is another way to check the levels besides a lumbar puncture (aka spinal tap - PAINFUL!) for serum to test? 2) Research has shown that use of QEEG's and fMRI's allow detailed brain mapping to be done. It shows how the brain reacts to various stimuli related to pain and proves that FM patients react at much higher levels than healthy subjects. Has anyone had this done? My doctors have laughed at me in requesting these tests, saying insurance won't pay for them because there is no cure for the information that would be provided. This seems prejudicial to me, as one of the main problems in FM has been finding an objective, quantitative test. So we have it and it would provide us with a diagnosis that insurance companies would have to acknowledge...Why is this not happening? One of the top neurologists in the tri-state area told me that I have no shot at getting this testing paid for, which leads me to the conclusion that I can only access it by finding a clinical trial that involves it. Now once we have the proof, what to do with it? Again, why is all this testing being repeated, yet no one seems to be working on a method to adjust those malfunctions in the brain? When it comes down to it, the most progressive trials toward a cure are being conducted everywhere but in the USA. Yet trials for drugs to treat symptoms are abundant here. Drugs keep us running on the hamster wheel, addicting us to chemicals, and fattening the pockets of pharmaceutical companies and doctors who treat symptoms. Funny how our medical system is a for-profit industry, and these other countries have socialized medicine. Anyway, please sound off with any experiences you may have had in these steps toward a cure, or just what you've learned about this progress and your opinions. Thanks and hope you're having a pain-free day.