Has anyone taken or ordered Avemar?

Discussion in 'Fibromyalgia Main Forum' started by ulala, May 3, 2009.

  1. ulala

    ulala New Member

    Posted by waltz-"Avemar is a drug (supplement) that is used against cancer. And K. Loomis says it along with Immunovir and ImmunoPro (undenatured whey) helped her son. (Personal anecdote, not foundation advice)."



    from an Internet site about cancer treatment:

    My good friend has been taking Avemar for 4 years now and is doing famously!!! She purchases it from the Australian company at www.avemar.com.au They have a good reputation for posting all around Australia and to other countries in heat resistant packaging. There are so many trials and studies continuing all around the world with Avemar. I believe there is about to be a study done in Australia for the first time. To view the latest published studies go to www.avemar.com [the Hungarian site] and click on ‘scientific papers’. There are now 52 publications!!! The Hungarian site is info only. This company does not sell the product. The reason the product is cheap in Hungary is because it is government subsidized, just as it is in Austria. Let’s hope the same thing can happen in some other countries soon.
  2. TeaBisqit

    TeaBisqit Member

    The prices on the Aussie site are insane. I could never afford that.
  3. ulala

    ulala New Member

    last week. I wish I had known about this before she left. There must be ways of getting it at better prices.

    Avemar is fermented wheat germ powder or extract (FWGE) or (FWGP).

    From Wikipedia, the free encyclopedia

    (April 2008)

    Fermented wheat germ extract (FWGE), also called fermented wheat germ powder (FWGP) is a concentrated extract of wheat germ fermented by baker's yeast, used primarily for its ability to stimulate and modulate immune system function. The fermented wheat germ extract was invented by Mate Hidvegi, a Hungarian chemist in the early '90s.

    FWGP is approved as a medical nutriment for supportive therapy of cancer in Hungary and is used for that purpose in other nations of the European Union (EU), and in parts of the Middle East and Asia. It is used in the US as a dietary supplement.

    In addition to its use in support of treatments for cancer, in which immune system function usually is impaired prior to and/or following cytotoxic treatment, FWGE has also been studied for use in conditions in which the immune system is inappropriately over-active, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

    The use and study of FWGE in conditions at such widely distant points on the spectrum of abnormal immune system function as cancer -- in which immune system function often is impaired -- and autoimmune conditions -- in which immune system function is inappropriately overactive -- occurs because the extract has been shown to support normal immune system function and normal cell metabolism.

    FWGE is derived from the germ (endosperm, or seed) of the wheat plant, and is a by-product of milling of wheat kernels to produce flour. FWGE differs from ordinary wheat germ in that it is fermented to concentrate the substituted benzo-quinones, which are biologically active. Concentration allows the immunomodulatory effects of the substituted benzo-quinones to be obtained without the consumption of impractically large amounts of wheat germ. FWGE (trade names Avemar, Avé) is identified in some research studies by the laboratory code name MSC. In proprietary formulations, the extract is standardized (formulated to always contain a specific amount of substituted benzo-quinones in a given amount of extract).

    Like many other naturally occurring substances extracted from plants, FWGE was historically mainly the provence only of naturopathic doctors, holistic health practitioners, and herbalists. Currently, such substances are increasingly of interest to more conventionally trained physicians who study them for use in those instances in which adequate, peer-reviewed published research has demonstrated substantial and quantifiable benefit.

    Contents [hide]
    1 Summary of laboratory and clinical research results
    2 Human clinical trials
    3 FWGP and automimmune diseases
    4 Animal studies
    5 Cell studies
    6 History of Development of FWGP
    7 Summary
    8 References
    9 External links



    [edit] Summary of laboratory and clinical research results
    Results of cell studies, animal studies, and human clinical trials focused on cancer show that FWGE has exhibited significant anti-cancer effects in a broad variety of cancer types and also positive effects in auto-immune diseases [1].


    [edit] Human clinical trials
    FWGE improved survival, and reduced new recurrences and metastases in colorectal cancer patients. When used in a study of 170 post-surgical colorectal cancer patients also receiving standard of care therapy such as chemotherapy, and/or radiation, addition of FWGE reduced new recurrences by 82%, metastases by 67%, and deaths by 62%, compared to use of radiation and chemotherapy alone. It also lengthened the time it took for cancer to become measurably active again after primary therapy (surgery) and adjuvant therapy (chemotherapy and/or radiation treatment). [2]

    In pediatric cancer patients with various cancer types, FWGE substantially reduced the risk of infections accompanied by high fever (febrile neutropenia), primarily by boosting immune system cell populations and activity. In pre-clinical tests specifically looking at immune effects, FWGP accelerated recovery of immune function following radiation and chemotherapy, inhibited immune suppression, improved NK cell recognition of target cells, and supported normal immune system function that helps white blood cells to cross through blood vessel walls and into tumors. [3]

    In a melanoma study, of patients with advanced-stage (Stage III) melanoma skin cancer, FWGE added to chemotherapy resulted in a 1-year relapse-free survival rate of 54.5%, compared to 38.9% for those getting only chemotherapy.

    Pre-clinical research done earlier may explain some of the compound’s antimetastatic effects; it inhibited cell proliferation and cell adhesion, and demonstrated promotion of apoptosis and antioxidant effects. [4]

    In an oral cancer study, FWGP used as supportive therapy for patients undergoing standard anticancer therapies (SAT) for locally advanced squamous cell carcinoma of the mouth, FWGP reduced the risk of cancer progression by 85%.

    Because opportunities to exploit the mechanisms of action through which FWGP works (limiting access to pathways preferred by tumor cells for ribose synthesis, for example) may exist in many types of cancer, research is ongoing to learn if the results seen in colorectal cancer, melanoma skin cancer, and pediatric cancers will occur in other types of cancer.

    In pre-clinical tests to determine whether FWGP might interfere with conventional therapy, the compound did not lessen the therapeutic benefit of any conventional therapy. [5] In another study, therapeutic effects of some conventional treatments used in combination with FWGP were increased, e.g., reduced metastasis, [6] and in some cases those effects were accompanied by lessened frequency and severity of common side effects of conventional treatments, such as nausea, fatigue, weight loss and immune suppression. [7] In quality of life (QOL) tests, FWGP improved cancer patients’ perception of their quality of life.


    [edit] FWGP and automimmune diseases
    Results of early research using FWGE in autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) suggest FWGE may be of use in these diseases for its ability to reduce inflammatory cytokines and rebalance the activity of Th1 and Th2 lymphocytes. [8] Clinical trials are underway to learn more about FWGP’s effects in SLE.


    [edit] Animal studies
    In animals with transplanted human lung cancer, FWGE added to chemotherapy increased survival markedly. [9]

    In rats exposed to a substance known to cause colon cancer (AOM), giving the rats FWGE reduced by 46% the number of animals developing colon cancer and reduced the size and number of tumors in those rats that did develop colon cancer. [10]

    In mice with a variety of cancer types (highly metastatic lung cancer; melanoma, and human colon cancer), FWGP administered with vitamin C reduced metastasis (spread) of the cancers. [11]

    Toxicity studies with FWGE showed no toxicity at levels several times above the amounts recommended for use.


    [edit] Cell studies
    In a colon cancer cell study, FWGE caused 22% of the cancer cells to die due to apoptosis, and 28% due to direct cell-killing by FWGP. [12]

    In estrogen-positive breast cancer cells, adding FWGP to tamoxifen treatment killed more breast cancer cells than tamoxifen alone, mainly by increasing apoptosis. [13]

    In T-cell and B-cell lymphoma cells, FWGP increased destruction of cancerous cells via forcing more cells into apoptosis. [14]

    In tests against leukemia cells, FWGE controlled cell growth and proliferation, mainly by inhibiting enzymes needed to make new DNA to support replication of leukemic cells and by triggering apoptosis. [15]

    In cell studies of pancreatic cancer, FWGE limited the creation of new pancreatic cancer cells by limiting cancer cells’ access to glucose, needed to make the sugar ribose for DNA and RNA for new cancer cells. [16]

    In human and animal myeloid leukemia cells, and human cervical cancer cells, researchers found FWGE limited the growth and decreased the survival of the cancer cells, mainly by increasing quantities or activity of specific cell hormone-like substances called cytokines, such as tumor necrosis factor (TNF), which harm cancerous cells but not normal cells. [17]

    In a 1983 study done by Szent-Gyorgyi and colleagues, Erlich tumor cell acites were eliminated from mice using a combination of DMBQ, one of the naturally occurring compounds in FWGP, and ascorbate. The study authors said they believed the elimination was likely due to the interaction of the acites cells and very short-lived free radicals produced by the combination. [18]

    Work by Szent-Gyorgyi and colleagues in 1985 showed the compound’s effects against the acites tumor cells was likely at least partly due to one of the active ingredients in FWGE causing a loss of NAD(P)H reducing power in the cells. [19]


    [edit] History of Development of FWGP
    FWGP is approved as a medical nutriment in support of therapy for cancer in Hungary, where it was first developed. It is used throughout Europe, and in parts of the Middle East and Asia, which have a history of use of foods and food-derived factors as medically beneficial that is older than in some other parts of the world.

    Investigation into the biological properties of fermented wheat germ was initiated by Hungarian biochemist Albert Szent-Gyorgyi (Nobel Prize in Physiology or Medicine in 1937: discovery of vitamin C). In the later years of his career, Szent-Gyorgyi focused his research on causes of and possible treatments for cancer, a disease that had taken the lives of his first wife, his daughter, and other family members.

    An expert in cellular respiration and metabolism, Szent-Gyorgyi was a strong proponent of Hippocrates' concept of using foods as medicine. His observation that people eating refined grains developed chronic diseases such as cancer more often than those who ate whole grains led Szent-Gyorgyi to investigate biological properties of wheat germ to learn if it might be useful against cancer. Scientists already knew that cancer cells use huge amounts of glucose, compared to normal cells [the Warburg effect]. Aware that rapid metabolism of glucose could support development, growth and proliferation of cancer cells, Szent-Gyorgyi looked for substances in the wheat plant that might help explain the lower cancer rates among those eating whole grains.

    In a series of early papers on wheat germ published in research journals, Szent-Gyorgyi showed results and anaylses suggesting that certain natural compounds called quinones, specifically methoxy-sustituted benzoquinones, naturally present in wheat germ, could help regulate cell metabolism, and possibly prevent the kind of overuse of glucose that supports cancer cell growth and replication.

    Fermenting wheat germ with baker’s yeast concentrated the most effective metabolism-regulating quinones such as 2,6-DMBQ, Szent-Gyorgyi noted, so they could be taken as a supplement without the need to consume impractically large amounts of wheat germ.

    But large-scale fermentation processes were insufficient then to produce large quantities of the powder, so Szent-Gyorgyi had the same problem he'd faced earlier working to isolate vitamin C: not enough isolated concentrate to use in further lab tests. And the problem of how to standardize the compound’s content, to ensure the same amount of active molecules in each given amount of the powder remained to be solved. Those problems remained unsolved at the time of Szent-Gyorgyi’s death in 1986.

    Szent-Gyorgyi’s work was later picked up by Mate Hidvegi, starting in the 1990s. Hidvegi and his research team used new industrial-scale fermentation processes to produce large quantities of extract, and succeeded in standardizing the amount of active substances in any given amount of it. When initial cell and animal studies showed slowed tumor cell growth, increased cancer cell death by apoptosis, reduced metastasis, and other apparent benefits, human clinical trials were initiated. Currently, FWGE is approved in Hungary and several other European Union (EU) nations as a medical nutriment in support of cancer therapy, and is in use in the US as a dietary supplement.


    [edit] Summary
    Fermented Wheat Germ Extract (FWGE) is a powdered concentrate of a fermented plant extract, approved in Europe as a medical nutriment for support of therapy for cancer, and used in the US as a dietary supplement. Research has shown FWGE to support normal immune system and cell metabolic function, to support NK cell targeting ability and coordination of immune system activities such as the responses of macrophages, B-cell and T-cells, and to support cellular and humoral (Th1 and Th2) balance. Effects seen in cell, animal, and human clinical cancer research studies may explain its use in the US and Europe in a wide variety of conditions in which support of normal, as opposed to abnormal, metabolism and immunity, are viewed as important. Research with the substance continues at academic and medical institutions in the US, the EU, and in Asia.



    Results of early research using FWGE in autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) suggest FWGE may be of use in these diseases for its ability to reduce inflammatory cytokines and rebalance the activity of Th1 and Th2 lymphocytes. [8] Clinical trials are underway to learn more about FWGP’s effects in SLE.



    The Aussie site-1 box $239.00 for one month supply
    [This Message was Edited on 05/03/2009]
    [This Message was Edited on 05/03/2009]
  4. ulala

    ulala New Member

    Wheat germ extract
    Healthcare Professional Consumer

    How It Works
    Purported Uses
    Research Evidence
    Warnings
    Do Not Take If
    Side Effects
    Common Name
    Brand Name
    Clinical Summary
    Purported uses
    Constituents
    Mechanism of Action
    Warnings
    Contraindications
    Adverse Reactions
    Herb-Drug Interactions
    Literature Summary and Critique
    References


    How It Works
    Bottom Line: Fermented wheat germ extract has been shown to improve quality of life in some cancer patients.

    Fermented wheat germ extract (WGE) was developed by Mate Hidvegi, a Hungarian chemist, in the 1990s. It should not be confused with wheat germ oil. WGE is used as a dietary supplement by cancer patients in Hungary to improve quality of life. Laboratory studies show that WGE may have anticancer properties. Results from some clinical trials suggest WGE improves quality of life in some cancer patients. This product is associated with some adverse effects. Patients should consult their physicians before taking any supplements.
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    Purported Uses
    Cancer Treatment
    WGE was shown to improve quality of life in cancer patients but more data is needed to establish its use.
    Autoimmune Diseases
    Studies done in mice showed that WGE is beneficial but human data is lacking.
    Immunostimulation
    Data from in vitro and observational studies indicate that WGE has immunomodulatory effects.
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    Research Evidence
    Cancer Treatment:
    This study was done to determine the benefits of WGE for patients with colorectal cancer. Sixty-six patients were given WGE (9g once daily) along with cancer treatments whereas 104 patients received only cancer treatments. Results showed WGE had improved overall survival compared to those in control group.

    Another study involved twenty-two children with different cancers. Eleven of them were given 12g/m2/day of WGE during cancer treatments whereas eleven others received only cancer treatments. Researchers found the overall white blood cell and lymphocyte counts were close to normal values in the WGE group compared to those in the control group.
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    Warnings
    WGE should be taken under medical supervision only. Patients with hormonal-sensitive cancers should use it with caution. Diabetics should be careful because of the carbohydrate content of WGE.

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    Do Not Take If
    You are pregnant or nursing
    You had an organ or tissue transplant
    You have bleeding, ulcers of the stomach and intestine, or severe absorption problem
    You have sensitivity to gluten
    You are fructose intolerant

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    Side Effects
    Mild and infrequent side effects may include diarrhea, nausea, flatulence, soft stool, constipation, dizziness. Long term use of WGE may result in increased body weight.

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    Common Name
    Fermented Wheat germ extract, MSC (Code Name)
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    Brand Name
    Avemar
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    Clinical Summary
    Fermented wheat germ extract (WGE) was developed by Mate Hidvegi, a Hungarian chemist, in the 1990s. It should not be confused with wheat germ oil. WGE is used as a dietary supplement by cancer patients in Hungary to improve quality of life. Results from in vitro studies show that WGE has anticancer (1) (2) (12) , antimetastatic (3), and immunomodulatory (2) (4) effects. It was also shown to increase estrogen receptor (ER) activity in vitro. However, when used along with tamoxifen, an ER antagonist, it enhanced efficacy of tamoxifen in ER positive breast cancer cells (5). The antitumor effect of WGE is comparable to other endocrine treatments in animal model (11). WGE also increased production of tumor necrosis factor and cytokines that are responsible for tumor cell death (6). Data from pilot studies implicates a beneficial role for WGE in patients with colorectal cancer (7) and in reducing treatment associated febrile neutropenia in pediatric cancer patients (8). Another pilot study showed that WGE can prolong survival of patients with melanoma when used with chemotherapy (13). However, these effects must be confirmed by large scale, well-designed clinical trials. Because it potentiates estrogen receptor activity, patients with hormonal sensitive cancers should use WGE with caution. Reported mild side effects include diarrhea, nausea, flatulence, soft stool, constipation, and dizziness. Long term use of WGE may result in increased body weight (10).

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    Purported uses
    Autoimmune diseases
    Cancer treatment
    Immunomodulation
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    Constituents
    Wheat germ
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    Mechanism of Action
    Although the exact mechanism of action is not clear, WGE was shown to increase TNF and cytokine production in vitro by activating certain metabolic pathways (6) involved in tumor cell death. WGE also regulates tumor cell proliferation by inhibiting glycolysis and pentose cycle enzymes and induces apoptosis through caspase-3-mediated poly (ADP ribose) polymerase cleavage (4).
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    Warnings
    WGE should be taken under medical supervision only. Diabetics should use this product with caution because of the high carbohydrate content.
    (10)
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    Contraindications
    Pregnant and nursing women
    Patients with organ or tissue transplants
    Patients with bleeding gastric or duodenal ulcers, enteritis/colitis, malabsorption syndrome.
    Patients with sensitivity to gluten and those with fructose intolerance.
    (10)
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    Adverse Reactions
    Mild and infrequent side effects may include diarrhea, nausea, flatulence, soft stool, constipation, dizziness. Long term use of WGE may result in increased body weight.
    (10) (13)

    WGE may have estrogen receptor activity. Patients with hormonal-sensitive cancers should consult with a physician before using WGE.
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    Herb-Drug Interactions
    WGE should be taken at least two hours before or after consuming vitamin C.
    (10)
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    Literature Summary and Critique
    Jakab F, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. British Journal of Cancer 2003; 89:465-469.
    This study was done to determine if WGE supplementation was beneficial for patients with colorectal cancer. Sixty-six patients were given WGE (9g once daily) in addition to anticancer treatments and 104 patients received only anticancer treatments. Data analysis revealed that patients who took WGE had fewer disease progression-related events compared to the control group. There was also an improvement in overall survival of patients on WGE. But more trials are needed with equal number of patients in the experimental and control groups.

    Garami M, et al. Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients. J Pediatr Hematol Oncol 2004; 26(10): 631-635.
    Twenty-two pediatric patients with different malignant tumors participated in this study. Eleven patients were given 12g/m2/day of WGE during cancer treatments and eleven patients received only cancer treatments. Researchers found that there was no recognizable progression of disease during the follow-up period. But there was a significant difference in the frequency of febrile neutropenic events between the two groups. The overall white blood cell and lymphocyte counts during such events were close to normal values in the WGE group compared to those in the control group. Since this is a pilot study, randomized controlled trials are warranted with larger sample size to verify these effects.
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  5. ulala

    ulala New Member

    Apr-03-07, 05:13 PM (PST)

    "Fermented wheat germ extract vs. Warburg effect"

    It's very interesting that DCA works by interfering with the Warburg effect. Basically, it forces cancer cells to use the same kind of glucose metabolism that normal cells do.
    There is another substance, this one a plant extract, that interferes with the Warburg effect as well, forcing cancer cells into apoptosis (cell suicide) but doesn't cause peripheral neuropathy (nerve damage). It's a concentrated extract of fermented wheat germ compounds and has an enormous amount of research behind it. It's called Avemar (Ave in the US) and is approved in Hungary as a medical nutrment in support of cancer patients undergoing therapy. It's widely used in Europe and became available in the US in 2005.

    In colorectal cancer, it improved survival rates and lengthened disease-free periods, and reduced metastasis. In children with a variety of solid tumors, it radically reduced the side-effects of chemo and radiation and helped the immune system endure those treatments without the usual threat of low white blood cell counts and high-fever (febrile neutropenia). It was developed by scientists following the work of Albert Szent-Gyorgyi, who won the Nobel Prize for first isolating vitamin C. He was a contemporary of Otto Warburg, and was well aware of the importance of stopping the Warburg effect if you're going to stop cancer.

    Ave is NOT a cure for cancer, but as a medical writer focused on progress against cancer, I've personally talked with MDs, NDs, and clinical oncology nutritionists who speak in quietly awed voices about how big a difference this extract has made in the lives of their patients. Because it lessens chemo side effects and helps keep white blood cell counts in the normal range without the risks from pharma drugs that build red and white blood cell counts, it has made the difference between patients being able to continue taking therapy and having to wait for the immune system to recover. Research I've read on PubMed shows it boosts the efficacy of conventional treatment while lessening side effects in a variety of different kinds of cancer. That can allow an oncologist to provide a patient the same effects from less chemo.

    Anyone interested in learning more about Ave and Avemar can find the research on PubMed (www.pubmed.gov ) or at (www.avemarresearch.com ). Toxicology experts reporting on it said it "has the safety profile of bread."

    Whether we like it or not, for many cancer patients today, chemotherapy may in reality be the best hope for prolonging our lives, getting us into the future where newer, kinder, gentler, cancer treatments hopefully await us all. Avemar clearly helps people do that. It's not available everywhere, but Whole Foods carries it in some cities, and it can be ordered from the US distributor, which you can probably find on Google.

    I hope this is helpful. Also, if you are using DCA and because of that, taking large amounts of thiamin (more than the RDA) to stave off nerve damage, PLEASE let your doctor know about the thiamin, and if your doc seems puzzled by concern about thiamin (it can help spur cancer cell growth when the Warburg effect is present), please ask him or her to research thiamin and cancer and get back with you on that.






  6. Forebearance

    Forebearance Member

    Hi ulala,

    Yes, I just ordered some. I had considered it a while ago and had decided it was too expensive to try just for an experiment.

    Now that I know more about what's going on with my immune system, it sounds like something that might be helpful for me. So I decided it was worth trying. I'm pretty willing to be a guinea pig with things that seem like they won't hurt me. I'll let you know how it does!

    Forebearance
  7. ulala

    ulala New Member

    That's great that you ordered the Avemar! Where did you order from? I saw that Swanson's has it for $127.00. I think its expensive to ship it because it has to be refrigerated. Did you order Ave or Avemar? From what I read it's called Ave in the U.S. and Avemar out of the U.S? It's a little confusing.

    Avemar certainly sounds like it would be something that could help us. It doersn't seem to have any bad side effects.

    I can't wiat to hear about your experience with it. I hope it's as good as it sounds for you! Goiod luck!
  8. Forebearance

    Forebearance Member

    Hi ulala,

    I ordered the Ave from the official site. (I live in the US.) I didn't do research online to see who might sell it cheaper, and of course I regret that now! I paid around $200 for it.

    It's a little surprising that something made from wheat and yeast could be good for CFS patients! lol I guess I'll find out.

    I know now that some of my cytokines are way high because of being poisoned by mold toxins, so it will be interesting to see if the Ave can help me feel better by bringing my immune system more into balance. I wonder if it will even have an effect on someone with mold poisoning.

    I also have very light skin and have an AK on my scalp, so I'm hoping the Ave might help with preventing it from turning into skin cancer.

    Forebearance