I just recently posted the other day about herbs or supplements to help fatigue but I'm posting again. Has anyone had any luck with `effexor or wellbutrin to help combat fatigue. Also did anyone ever experience a decrease in pain with the effexor? Any suggestions would help. I'm curently taking trazodone and lexapro at night and sleeping like a baby (10 hours uninterrupted) but I have overwhelming fatigue during the day. I'm desperate.