I was diagnosed many years ago with fibromyalgia after going from dr. to dr. trying to find out exactly what was causing my horrible pain, which started out with head/neck pain. After giving up on medications that didn't work, I somehow learned to live in pain for about ten years. Finally decided that I was so tired of living like that, and went to my very progressive family doctor and cried my eyes out asking for help. He told me that he had a few patients with chronic unexplained pain (due to low seratonin levels supposedly) that had success with anti-depressants. He put me on Effexor XR (225mg.) Within six weeks after starting the Effexor, most of the horrible head pain was gone...what a miracle for me! I was on the Effexor for about five years. Because of going on some other meds. (Lipitor and Hydrochlorothiazide), I decided that I just didn't want to take so much medication, so with my drs. okay, I came off the Effexor. In the meantime, I developed a low back problem, but never had the head pain again...until about four days ago. I've been off of the Effexor for exactly one year. I wonder why the horrible head/neck pain would suddenly re-appear after a year? Anyway, the pain is not like a migrane or cluster headache. It feels like the pain is allover, not just on one side...sort of like my whole head is in a vice, and it doesn't throb at all, but it's there constantly and it's bad. Has anyone out there had head pain like this? I'm sorry this is so long, but I'm just very upset tonight. Anyway, I went to the doctor today, and I'm having bloodwork done to make sure the Lipitor isn't contributing to my muscle pain. Since I told my dr. that the pain is exactly like it was before I ever went on the Effexor, she's putting me back on the Effexor to see if it makes a difference. I'm usually a very optomistic person, but the pain is really starting to get to me emotionally. Thanks for listening to me rant on!