Hair analysis verified low levels of mercury, but toxic levels of Cadmium, Lead, Antimony & Arsenic. I had already used two bottle of DMSA 100mg X 45 capsules, on suspicion of mercury. It worked real well on the mercury. Dr. Cinque of 1to1vitamins now recommends that I take EDTA and ALA as they work better on the other metals. When I chelate, I feel worse: tired, kidneys hurt, headache, depression. After 3 days, I'm resting and taking my mineral supplements again and WOW, I do feel better: Less brain fog, less anxiety, better outlook so the depression is less. I was reading the literature from BodyBalance that came with the hair analysis: it emphasized that toxic metals can interfere with our body's enzymatic reactions and mess up thousands of reactions. Enzymes are amino acids with a metal attached. If a toxic metal attaches itself, extreme changes can take place. Some metals work as antagonists: Zinc and Cadmium Lead and Calcium The bones breath calcium and, in my case, lead, so it will take several cycles to chelate it all out...but I feel better with the first cycle!!!!