I'm new to this board; been over at CFS board for some time. I've been taking TF 540 for about a year and a half, two caps a day. I can't tell how much it helps because I have radically changed my diet also and that HAS worked really well. I am better than I've ever been since becoming sick. BUT... I ran out last fall, and didn't bother to get more. About three weeks later I felt as though I was getting EBV all over again, flu-ey. I quickly ordered some more, and I won't experiment again! Either a coincidence, or the stuff works!! Madelyn CFIDS since 1994, but gradually since 89. Age 43 with a happy family life!