Hi.....I tried to call the doc but she won't be in until tomorrow. I have CFS/Fibro/Thyroiditis. I felt the zoloft wasn't working anymore....I was down mentally more than I was up. So she recommended I try Cymbalta, 30 mgs. to start. Well, I've been taking it for 3 weeks now and I swear I am so depressed I can't even function, I cry at the drop of a hat. Maybe the zoloft wasn't so bad after all? When do you know to say to the doc........this isn't working for me??? Any and all advice welcome dear friends.