I am having unrelenting itchiness in my larger muscles. Thighs, calfs, upper arms and inside of knees. It is making me crazy. If I scratch to much or to hard I come up bruised. Cortate cream helped some. I have been taking Zanaflex for a year now, could my body be rejecting? I haven't started anything new. I am calling my doc tomorrow. Have also had increased muscle pain for the last week. I have really been feeling terrible. Very lonely in my pain. Bye for now, Valley.